about
Second AKT: the rise of SGK in cancer signallingDual requirement for a newly identified phosphorylation site in p70s6kTargeting the nucleolus for cancer interventionDual posttranscriptional targets of retinoic acid-induced gene expressionThe inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation.Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation.Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell populationmTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy.Regulatory and structural motifs of chicken gizzard myosin light chain kinase.Dysregulation of RNA polymerase I transcription during disease.Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells.Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity.AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.Intrasteric regulation of protein kinases and phosphatases.Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function.Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations.The multi-layered regulation of copper translocating P-type ATPases.Role of basic residues in the phosphorylation of synthetic peptides by myosin light chain kinase.Class IA phosphatidylinositol 3-kinase signaling in non-small cell lung cancer.Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcriptionThe Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.Therapeutic Approaches Targeting MYC-Driven Prostate CancerTargeting PI3 kinase/AKT/mTOR signaling in cancer.Dysregulation of the basal RNA polymerase transcription apparatus in cancer.AKT-independent PI3-K signaling in cancer - emerging role for SGK3.Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors.PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity.Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition.A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth.Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase.Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex.S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila.Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling.The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.STIM1: a novel phosphoprotein located at the cell surface.Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.Too much or too little: harnessing senescence to control oncogene-driven cancer.Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase.In silico modeling of the Menkes copper-translocating P-type ATPase 3rd metal binding domain predicts that phosphorylation regulates copper-binding.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Rick Pearson
@ast
Rick Pearson
@en
Rick Pearson
@es
Rick Pearson
@nl
Rick Pearson
@sl
ريك بيرسون
@ar
type
label
Rick Pearson
@ast
Rick Pearson
@en
Rick Pearson
@es
Rick Pearson
@nl
Rick Pearson
@sl
ريك بيرسون
@ar
prefLabel
Rick Pearson
@ast
Rick Pearson
@en
Rick Pearson
@es
Rick Pearson
@nl
Rick Pearson
@sl
ريك بيرسون
@ar
P1053
I-1451-2013
P106
P21
P31
P3829
P496
0000-0001-5919-5090