Role of ATP-binding cassette and solute carrier transporters in erlotinib CNS penetration and intracellular accumulation.
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Research Progress of Mechanisms on Intracranial Metastasis of Non-small Cell Lung Cancer after Clinical Benefit from EGFR-TKIRole of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistanceIn silico prediction of inhibition of promiscuous breast cancer resistance protein (BCRP/ABCG2)Systemic therapy of brain metastases: non-small cell lung cancer, breast cancer, and melanoma.Efficacy of increased-dose erlotinib for central nervous system metastases in non-small cell lung cancer patients with epidermal growth factor receptor mutation.Interaction of innovative small molecule drugs used for cancer therapy with drug transporters.Brain metastases from renal cell carcinoma in the era of tyrosine kinase inhibitors.Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance.Activation of alternate prosurvival pathways accounts for acquired sunitinib resistance in U87MG glioma xenografts.Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer.Function of the blood-brain barrier and restriction of drug delivery to invasive glioma cells: findings in an orthotopic rat xenograft model of glioma.Pharmacokinetic Properties of Anticancer Agents for the Treatment of Central Nervous System Tumors: Update of the Literature.EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesisDevelopment and evaluation of a novel microemulsion formulation of elacridar to improve its bioavailability.Efflux transporters in the blood-brain interfaces--in vitro and in vivo methods and correlations.EGFR mutation status in brain metastases of non-small cell lung carcinoma.Mechanism of chemoresistance against tyrosine kinase inhibitors in malignant glioma.Overview of experimental models of the blood-brain barrier in CNS drug discovery.Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance.Physicochemical properties of novel protein kinase inhibitors in relation to their substrate specificity for drug transporters.Classical and Targeted Anticancer Drugs: An Appraisal of Mechanisms of Multidrug Resistance.The Role of Transporters in the Toxicity of Chemotherapeutic Drugs: Focus on Transporters for Organic Cations.Targeted Treatment of Brain Metastases.Combined Microdialysis-Tumor Homogenate Method for the Study of the Steady State Compartmental Distribution of a Hydrophobic Anticancer Drug in Patient-Derived Xenografts.Magnetic resonance imaging-guided microdialysis cannula implantation in a spontaneous high-grade glioma murine model.Population pharmacokinetics/pharmacodynamics of erlotinib and pharmacogenomic analysis of plasma and cerebrospinal fluid drug concentrations in Japanese patients with non-small cell lung cancer.Leptomeningeal metastasis from systemic cancer: Review and update on management.Influence of OATPs on Hepatic Disposition of Erlotinib Measured With Positron Emission Tomography.EGFR heterogeneity and implications for therapeutic intervention in glioblastoma.The use of microdialysis techniques in mice to study P-gp function at the blood-brain barrier.TKI combination therapy: strategy to enhance dasatinib uptake by inhibiting Pgp- and BCRP-mediated efflux.Impact of nutritional status on the pharmacokinetics of erlotinib in rats.The effect of rifampicin, a prototypical CYP3A4 inducer, on erlotinib pharmacokinetics in healthy subjects.Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in rats
P2860
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P2860
Role of ATP-binding cassette and solute carrier transporters in erlotinib CNS penetration and intracellular accumulation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Role of ATP-binding cassette a ...... nd intracellular accumulation.
@ast
Role of ATP-binding cassette a ...... nd intracellular accumulation.
@en
Role of ATP-binding cassette a ...... nd intracellular accumulation.
@nl
type
label
Role of ATP-binding cassette a ...... nd intracellular accumulation.
@ast
Role of ATP-binding cassette a ...... nd intracellular accumulation.
@en
Role of ATP-binding cassette a ...... nd intracellular accumulation.
@nl
prefLabel
Role of ATP-binding cassette a ...... nd intracellular accumulation.
@ast
Role of ATP-binding cassette a ...... nd intracellular accumulation.
@en
Role of ATP-binding cassette a ...... nd intracellular accumulation.
@nl
P2093
P2860
P1476
Role of ATP-binding cassette a ...... nd intracellular accumulation.
@en
P2093
Angel M Carcaboso
Clinton F Stewart
Michael Tagen
Mohamed A Elmeliegy
P2860
P356
10.1158/1078-0432.CCR-10-1934
P407
P577
2010-11-18T00:00:00Z