WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response. - Test2 - elhamkhani - TriplyDB

WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.

WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.

http://www.wikidata.org/entity/Q34480661

about

Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response HYAL-2-WWOX-SMAD4 Signaling in Cell Death and Anticancer Response Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells Wwox-Brca1 interaction: role in DNA repair pathway choice The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway.UV irradiation/cold shock-mediated apoptosis is switched to bubbling cell death at low temperatures Association of polymorphisms in WWOX gene with risk and outcome of osteosarcoma in a sample of the young Chinese population Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4.The common fragile site FRA16D gene product WWOX: roles in tumor suppression and genomic stability.WWOX, large common fragile site genes, and cancer.Pc2-mediated SUMOylation of WWOX is essential for its suppression of DU145 prostate tumorigenesis.HBXIP, a binding protein of HBx, regulates maintenance of the G2/M phase checkpoint induced by DNA damage and enhances sensitivity to doxorubicin-induced cytotoxicity.WWOX modulates the ATR-mediated DNA damage checkpoint response Recurrent alterations of the WW domain containing oxidoreductase gene spanning the common fragile site FRA16D in multiple myeloma and monoclonal gammopathy of undetermined significance.WWOX guards genome stability by activating ATM.WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma Current questions and controversies in chromosome fragile site research: does WWOX, the gene product of common fragile site FRA16D, have a passive or active role in cancer?Correlation between osteosarcoma and the expression of WWOX and p53.Tumor suppressor WWOX moderates the mitochondrial respiratory complex.Phosphorylation/de-phosphorylation in specific sites of tumor suppressor WWOX and control of distinct biological events.WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.Association of WWOX rs9926344 polymorphism with poor prognosis of hepatocellular carcinoma.Tumor Suppressor Gene in Breast Cancer, a Historical Perspective and Future Directions Modeling WWOX Loss of Function : What Have We Learned?Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer

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WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.

http://www.wikidata.org/entity/Q34480661

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2014 nî lūn-bûn

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2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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WWOX, the common fragile site ...... n and the DNA damage response.

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WWOX, the common fragile site ...... n and the DNA damage response.

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WWOX, the common fragile site ...... n and the DNA damage response.

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WWOX, the common fragile site ...... n and the DNA damage response.

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WWOX, the common fragile site ...... n and the DNA damage response.

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WWOX, the common fragile site ...... n and the DNA damage response.

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WWOX, the common fragile site ...... n and the DNA damage response.

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WWOX, the common fragile site ...... n and the DNA damage response.

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WWOX, the common fragile site ...... n and the DNA damage response.

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PNAS.1409252111

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Proceedings of the National Academy of Sciences of the United States of America

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WWOX, the common fragile site ...... n and the DNA damage response.

@en

P2093

Christoph Herbel

http://www.w3.org/2001/XMLSchema#string

Mohammad Abu-Odeh

http://www.w3.org/2001/XMLSchema#string

Rami I Aqeilan

http://www.w3.org/2001/XMLSchema#string

Thomas G Hofmann

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Zaidoun Salah

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P2860

Hallmarks of Cancer: The Next Generation

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

The ubiquitin-protein ligase Itch regulates p73 stability

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function

Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

Functional association between Wwox tumor suppressor protein and p73, a p53 homolog

Targeted deletion of Wwox reveals a tumor suppressor function

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