Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1. - Test2 - elhamkhani - TriplyDB

Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1.

Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1.

http://www.wikidata.org/entity/Q34497324

about

CoeViz: a web-based tool for coevolution analysis of protein residues.Benchmarking Inverse Statistical Approaches for Protein Structure and Design with Exactly Solvable Models.Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server Potts Hamiltonian models of protein co-variation, free energy landscapes, and evolutionary fitness.Improving landscape inference by integrating heterogeneous data in the inverse Ising problem.Inference of Epistatic Effects Leading to Entrenchment and Drug Resistance in HIV-1 Protease.ACE: adaptive cluster expansion for maximum entropy graphical model inference.Maximum-Entropy Models of Sequenced Immune Repertoires Predict Antigen-Antibody Affinity.Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis.Inferring repeat-protein energetics from evolutionary information.Inferring interaction partners from protein sequences.Connecting the Sequence-Space of Bacterial Signaling Proteins to Phenotypes Using Coevolutionary Landscapes.Identification of positive selection in genes is greatly improved by using experimentally informed site-specific models.Epistasis in protein evolution.Large-scale identification of coevolution signals across homo-oligomeric protein interfaces by direct coupling analysis.Random versus maximum entropy models of neural population activity.Mutation effects predicted from sequence co-variation.A Quantitative Model to Estimate Drug Resistance in Pathogens.Co-evolution techniques are reshaping the way we do structural bioinformatics.Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria.Fitness landscape of the human immunodeficiency virus envelope protein that is targeted by antibodies.Coevolutionary Landscape of Kinase Family Proteins: Sequence Probabilities and Functional Motifs.Patterns of coevolving amino acids unveil structural and dynamical domains.Exploring protein sequence-function landscapes.Biomolecular coevolution and its applications: Going from structure prediction toward signaling, epistasis, and function.How Many Protein Sequences Fold to a Given Structure? A Coevolutionary Analysis.Evolving Bacterial Fitness with an Expanded Genetic Code.Optimal Design of Experiments by Combining Coarse and Fine Measurements.Population-specific design of de-immunized protein biotherapeutics.Global pairwise RNA interaction landscapes reveal core features of protein recognition.Coevolution-based inference of amino acid interactions underlying protein function Designing bacterial signaling interactions with coevolutionary landscapes

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Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1.

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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Coevolutionary Landscape Infer ...... tions in Beta-Lactamase TEM-1.

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Coevolutionary Landscape Infer ...... tions in Beta-Lactamase TEM-1.

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Molecular Biology and Evolution

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Coevolutionary Landscape Infer ...... tions in Beta-Lactamase TEM-1.

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Alexander Schug

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Hervé Jacquier

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Matteo Figliuzzi

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P2860

Dissecting the specificity of protein-protein interaction in bacterial two-component signaling: orphans and crosstalks

Sequence co-evolution gives 3D contacts and structures of protein complexes

Thermodynamic prediction of protein neutrality

Direct-coupling analysis of residue coevolution captures native contacts across many protein families

Three-dimensional structures of membrane proteins from genomic sequencing

I-Mutant2.0: predicting stability changes upon mutation from the protein sequence or structure.

Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population genetics

An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

Increased folding stability of TEM-1 beta-lactamase by in vitro selection

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268-280

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10.1093/MOLBEV/MSV211

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1

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33

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Olivier Tenaillon

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1510.03224

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4693977

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