The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.
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Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspecklesNonsense-mediated mRNA decay: novel mechanistic insights and biological impactMechanism and regulation of the nonsense-mediated decay pathwayThe RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6Nonsense-mediated mRNA decay in humans at a glanceOrganizing principles of mammalian nonsense-mediated mRNA decayThe Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural OrganizationA novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.A novel role for hSMG-1 in stress granule formationN- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMDA network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylationHuman nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complexInhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity.Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay.Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1.NMD: a multifaceted response to premature translational termination.Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.Regulation of nonsense-mediated mRNA decay.Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human health.Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay.Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs.Mechanism, factors, and physiological role of nonsense-mediated mRNA decay.Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes.The Arabidopsis NMD Factor UPF3 Is Feedback-Regulated at Multiple Levels and Plays a Role in Plant Response to Salt Stress.eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells.Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins.The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.Conservation of Nonsense-Mediated mRNA Decay Complex Components Throughout Eukaryotic Evolution.Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Analysis of nonsense-mediated mRNA decay in mammalian cells.
P2860
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P2860
The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.
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2011 nî lūn-bûn
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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2011 թվականի հունվարին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
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2011年論文
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2011年论文
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name
The nonsense-mediated mRNA dec ...... l changes controlled by SMG-8.
@ast
The nonsense-mediated mRNA dec ...... l changes controlled by SMG-8.
@en
The nonsense-mediated mRNA dec ...... l changes controlled by SMG-8.
@nl
type
label
The nonsense-mediated mRNA dec ...... l changes controlled by SMG-8.
@ast
The nonsense-mediated mRNA dec ...... l changes controlled by SMG-8.
@en
The nonsense-mediated mRNA dec ...... l changes controlled by SMG-8.
@nl
prefLabel
The nonsense-mediated mRNA dec ...... l changes controlled by SMG-8.
@ast
The nonsense-mediated mRNA dec ...... l changes controlled by SMG-8.
@en
The nonsense-mediated mRNA dec ...... l changes controlled by SMG-8.
@nl
P2093
P2860
P356
P1433
P1476
The nonsense-mediated mRNA dec ...... al changes controlled by SMG-8
@en
P2093
Akio Yamashita
Ernesto Arias-Palomo
Israel S Fernández
Natsuko Izumi
Rafael Núñez-Ramírez
Yumi Bamba
P2860
P304
P356
10.1101/GAD.606911
P577
2011-01-01T00:00:00Z