Retroviral DNA integration: reaction pathway and critical intermediates.
about
Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)Herpesvirus telomeric repeats facilitate genomic integration into host telomeres and mobilization of viral DNA during reactivationRetroviral intasome assembly and inhibition of DNA strand transferVirological and cellular roles of the transcriptional coactivator LEDGF/p75LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integrationThe DNA damage response induced by infection with human cytomegalovirus and other virusesFoamy virus assembly with emphasis on pol encapsidationHIV-1 protease and reverse transcriptase control the architecture of their nucleocapsid partnerStructural basis for functional tetramerization of lentiviral integraseRetroviral intasomes search for a target DNA by 1D diffusion which rarely results in integrationFunctional and structural characterization of the integrase from the prototype foamy virusA Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.The mechanism of retroviral integration from X-ray structures of its key intermediatesStructural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based DesignCrystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding siteAssembly of prototype foamy virus strand transfer complexes on product DNA bypassing catalysis of integrationA possible role for the asymmetric C-terminal domain dimer of Rous sarcoma virus integrase in viral DNA bindingAllosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturationThe A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase InhibitorsMultimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors3′-Processing and strand transfer catalysed by retroviral integrasein crystalloStructural Basis of hAT Transposon End Recognition by Hermes, an Octameric DNA Transposase from Musca domesticaRetroviral Integrase: Then and NowEngineered hyperactive integrase for concerted HIV-1 DNA integrationRetroviral DNA IntegrationLEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivityHIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme.Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactorArchitecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linkingEfficient and specific internal cleavage of a retroviral palindromic DNA sequence by tetrameric HIV-1 integrase.The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.Mass spectrometry-based footprinting of protein-protein interactionsAn unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF.An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule.RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus.Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA bindingSolution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.
P2860
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P2860
Retroviral DNA integration: reaction pathway and critical intermediates.
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Retroviral DNA integration: reaction pathway and critical intermediates.
@ast
Retroviral DNA integration: reaction pathway and critical intermediates.
@en
Retroviral DNA integration: reaction pathway and critical intermediates.
@nl
type
label
Retroviral DNA integration: reaction pathway and critical intermediates.
@ast
Retroviral DNA integration: reaction pathway and critical intermediates.
@en
Retroviral DNA integration: reaction pathway and critical intermediates.
@nl
prefLabel
Retroviral DNA integration: reaction pathway and critical intermediates.
@ast
Retroviral DNA integration: reaction pathway and critical intermediates.
@en
Retroviral DNA integration: reaction pathway and critical intermediates.
@nl
P2093
P2860
P356
P1433
P1476
Retroviral DNA integration: reaction pathway and critical intermediates.
@en
P2093
Michiyo Mizuuchi
Robert Craigie
Terrence R Burke
P2860
P304
P356
10.1038/SJ.EMBOJ.7601005
P407
P577
2006-02-16T00:00:00Z