Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P(2) ligands: structure-activity studies and biological evaluation.
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Design of HIV-1 Protease Inhibitors with C3-Substituted Hexahydrocyclopentafuranyl Urethanes as P2-Ligands: Synthesis, Biological Evaluation, and Protein–Ligand X-ray Crystal StructureHighly Potent HIV-1 Protease Inhibitors with Novel Tricyclic P2 Ligands: Design, Synthesis, and Protein–Ligand X-ray StudiesSubstrate Envelope-Designed Potent HIV-1 Protease Inhibitors to Avoid Drug ResistanceDesign, Synthesis, and Biological and Structural Evaluations of Novel HIV-1 Protease Inhibitors To Combat Drug ResistanceIdentification of novel HIV 1--protease inhibitors: application of ligand and structure based pharmacophore mapping and virtual screeningOrganic carbamates in drug design and medicinal chemistryStructure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands.Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands.Structure-based design of potent HIV-1 protease inhibitors with modified P1-biphenyl ligands: synthesis, biological evaluation, and enzyme-inhibitor X-ray structural studiesInvestigational protease inhibitors as antiretroviral therapies.Tetrahydrofuran, tetrahydropyran, triazoles and related heterocyclic derivatives as HIV protease inhibitors.Enhancing protein backbone binding--a fruitful concept for combating drug-resistant HIV.Recent patents and emerging therapeutics for HIV infections: a focus on protease inhibitors.Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDSDesign and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.Scalable synthesis of oxazolones from propargylic alcohols through multistep palladium(II) catalysis: β-selective oxidative Heck coupling of cyclic sulfonyl enamides and aryl boroxines.Straightforward and highly diastereoselective synthesis of 2,2-di-substituted perhydrofuro[2,3-b]pyran (and furan) derivatives promoted by BiCl3.Design of Highly Potent, Dual Acting and Central Nervous System Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants.An enantioselective enzymatic desymmetrization route to hexahydro-4H-furopyranol, a high-affinity ligand for HIV-1 protease inhibitors.A neighboring group participation strategy: direct and highly diastereoselective synthesis of 2-substituted and 2,2-bisubstituted perhydrofuro[2,3-b]pyran derivatives.Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis.Lewis Acid Mediated Cyclizations: Diastereoselective Synthesis of Six- to Eight-Membered Substituted Cyclic Ethers.
P2860
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P2860
Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P(2) ligands: structure-activity studies and biological evaluation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
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name
Design and synthesis of potent ...... yranol-derived high affinity P
@nl
Design and synthesis of potent ...... ies and biological evaluation.
@ast
Design and synthesis of potent ...... ies and biological evaluation.
@en
type
label
Design and synthesis of potent ...... yranol-derived high affinity P
@nl
Design and synthesis of potent ...... ies and biological evaluation.
@ast
Design and synthesis of potent ...... ies and biological evaluation.
@en
prefLabel
Design and synthesis of potent ...... yranol-derived high affinity P
@nl
Design and synthesis of potent ...... ies and biological evaluation.
@ast
Design and synthesis of potent ...... ies and biological evaluation.
@en
P2093
P2860
P356
P1476
Design and synthesis of potent ...... dies and biological evaluation
@en
P2093
Abigail Baldridge
Arun K Ghosh
Bruno D Chapsal
Hiroaki Mitsuya
Melinda P Steffey
Yasuhiro Koh
P2860
P304
P356
10.1021/JM1012787
P407
P577
2010-12-31T00:00:00Z