Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
about
Short telomeres initiate telomere recombination in primary and tumor cellsThe genetics of dyskeratosis congenitaTelomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancerThe telomere syndromesMarkers of cellular senescence. Telomere shortening as a marker of cellular senescenceThe short and long telomere syndromes: paired paradigms for molecular medicineTelomerase and idiopathic pulmonary fibrosisAxis of ageing: telomeres, p53 and mitochondriaCellular mechanisms of tissue fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosisCancer stem cells: relevance to clinical transplantationATM Kinase Is Required for Telomere Elongation in Mouse and Human CellsLinking functional decline of telomeres, mitochondria and stem cells during ageingThe role of telomeres and telomerase in stem cell agingTelomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanismsA novel method for banking stem cells from human exfoliated deciduous teeth: lentiviral TERT immortalization and phenotypical analysisCell proliferation in the presence of telomerasemRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcriptionLoss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysemaPoly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA componentLow abundance of telomerase in yeast: implications for telomerase haploinsufficiency.Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.Telomeres and disease.A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis.Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenitaTelomerase gene mutations and telomere length shortening in patients with idiopathic pulmonary fibrosis in a Chinese population.Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomeraseTelomere lengths, pulmonary fibrosis and telomerase (TERT) mutations.FANCC suppresses short telomere-initiated telomere sister chromatid exchangeSyndromes of telomere shorteningTelomerase deficiency does not alter bleomycin-induced fibrosis in miceShort telomeres compromise β-cell signaling and survival.Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis.The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidenceCombined pulmonary fibrosis and emphysema.ELISA for aging biomarkers induced by telomere dysfunction in human plasma.A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.Telomerase and cancer stem cells.Telomerase RNA levels limit the telomere length equilibrium.Regulation of senescence in cancer and aging.Cancer stem cells-clinical relevance.
P2860
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P2860
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
@ast
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
@en
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
@nl
type
label
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
@ast
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
@en
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
@nl
prefLabel
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
@ast
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
@en
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
@nl
P2093
P50
P1433
P1476
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
@en
P2093
Baktiar Karim
David Huso
David M Feldser
Ling-Yang Hao
P304
P356
10.1016/J.CELL.2005.11.020
P407
P577
2005-12-01T00:00:00Z