The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.

The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.

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http://www.wikidata.org/entity/Q34565964
Preclinical animal anxiety research - flaws and prejudices.Structure, function, and modulation of GABA(A) receptorsPharmacological Properties of DOV 315,090, an ocinaplon metabolite.Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia.Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?Anxiolytic-like effects of mitragynine in the open-field and elevated plus-maze tests in rats.2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors.Contribution of alpha1 subunit-containing gamma-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeysAltered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects.The 5-HT6 receptor agonist EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration.
P2860

The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.

Item
http://www.wikidata.org/entity/Q34565964
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The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
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The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
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The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
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type
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The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
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The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
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The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
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The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
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The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
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The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
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The anxioselective agent 7-(2- ...... it-containing GABAA receptors.
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P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921