about
Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activitySelective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.Pharmacological Properties of DOV 315,090, an ocinaplon metabolite.Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular Ca2+ in cultured rat hippocampal neurons.Mapping of the alpha 4 subunit gene (GABRA4) to human chromosome 4 defines an alpha 2-alpha 4-beta 1-gamma 1 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster.The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.Sulfated steroids as endogenous neuromodulators.Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids.Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation.A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protonsThe neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism.Molecular and cellular mechanisms of GABA/benzodiazepine-receptor regulation: electrophysiological and biochemical studies.cAMP response element-binding protein, activating transcription factor-4, and upstream stimulatory factor differentially control hippocampal GABABR1a and GABABR1b subunit gene expression through alternative promoters.Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes.From ion currents to genomic analysis: recent advances in GABAA receptor research.Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatumGABA induces activity dependent delayed-onset uncoupling of GABA/benzodiazepine site interactions in neocortical neurons.Prenatal protein malnutrition reduces beta(2), beta(3) and gamma(2L) GABA(A) receptor subunit mRNAs in the adult septum.Inhibition of NMDA-induced striatal dopamine release and behavioral activation by the neuroactive steroid 3alpha-hydroxy-5beta-pregnan-20-one hemisuccinate.Differential expression of gamma-aminobutyric acid type B receptor subunit mRNAs in the developing nervous system and receptor coupling to adenylyl cyclase in embryonic neurons.Neurosteroid modulation of recombinant ionotropic glutamate receptors.Human GABA(B)R genomic structure: evidence for splice variants in GABA(B)R1 but not GABA(B)R2.Turnover and down-regulation of GABA(A) receptor alpha1, beta2S, and gamma1 subunit mRNAs by neurons in culture.Modulation of Neuronal Function through Benzodiazepine Receptors: Biochemical and Electrophysiological Studies of Neurons in Primary Monolayer Cell CultureThe inactivation of gamma-aminobutyric acid transaminase in dissociated neuronal cultures from spinal cordBenzodiazepine receptor synthesis and degradation by neurons in cultureA minimal promoter for the GABA(A) receptor alpha6-subunit gene controls tissue specificityGeometry and charge determine pharmacological effects of steroids on N-methyl-D-aspartate receptor-induced Ca(2+) accumulation and cell death
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
David H Farb
@ast
David H Farb
@en
David H Farb
@es
David H Farb
@nl
type
label
David H Farb
@ast
David H Farb
@en
David H Farb
@es
David H Farb
@nl
prefLabel
David H Farb
@ast
David H Farb
@en
David H Farb
@es
David H Farb
@nl
P106
P21
P31
P496
0000-0002-9050-6480