Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.
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The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth.HIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity.Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism.Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic UseTwin Resemblance in Muscle HIF-1α Responses to Hypoxia and Exercise.
P2860
Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.
description
2014 nî lūn-bûn
@nan
2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Intermediary metabolite precur ...... ing prolyl-4-hydroxylase PHD2.
@ast
Intermediary metabolite precur ...... ing prolyl-4-hydroxylase PHD2.
@en
Intermediary metabolite precur ...... ing prolyl-4-hydroxylase PHD2.
@nl
type
label
Intermediary metabolite precur ...... ing prolyl-4-hydroxylase PHD2.
@ast
Intermediary metabolite precur ...... ing prolyl-4-hydroxylase PHD2.
@en
Intermediary metabolite precur ...... ing prolyl-4-hydroxylase PHD2.
@nl
prefLabel
Intermediary metabolite precur ...... ing prolyl-4-hydroxylase PHD2.
@ast
Intermediary metabolite precur ...... ing prolyl-4-hydroxylase PHD2.
@en
Intermediary metabolite precur ...... ing prolyl-4-hydroxylase PHD2.
@nl
P2093
P2860
P1433
P1476
Intermediary metabolite precur ...... ing prolyl-4-hydroxylase PHD2.
@en
P2093
Chun-Ting Cheng
David K Ann
Jing-Ping Liou
Peifeng Hou
Qiang Chen
P2860
P304
P356
10.1371/JOURNAL.PONE.0113865
P407
P577
2014-11-24T00:00:00Z