Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells - Test2 - elhamkhani - TriplyDB

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

http://www.wikidata.org/entity/Q24683296

about

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase Applications of metabolomics in cancer research State of the science: an update on renal cell carcinoma Cancer metabolism and oxidative stress: Insights into carcinogenesis and chemotherapy via the non-dihydrofolate reductase effects of methotrexate Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics Reactive oxygen species in cancer stem cells Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel Pancreatic cancer early detection: expanding higher-risk group with clinical and metabolomics parameters Linking metabolism and epigenetic regulation in development of hepatocellular carcinoma HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium IDH mutations in tumorigenesis and their potential role as novel therapeutic targets.Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer Metabolic consequences of oncogenic IDH mutations Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies Metabolic modulation of glioblastoma with dichloroacetate Obesity and Diabetic Kidney Disease: Role of Oxidant Stress and Redox Balance Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104 Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha Iron control of erythroid development by a novel aconitase-associated regulatory pathway.A novel strategy involved in [corrected] anti-oxidative defense: the conversion of NADH into NADPH by a metabolic network.Interrogating IDH Mutation in Brain Tumor: Magnetic Resonance and Hyperpolarization.The tricarboxylic acid cycle, an ancient metabolic network with a novel twist.Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma Emerging Metabolic Therapies in Pulmonary Arterial Hypertension.Succinate is an inflammatory signal that induces IL-1β through HIF-1α.Novel two-step derivation method for the synchronous analysis of inherited metabolic disorders using urine.Metabolism and the leukemic stem cell.Metabolic basis to Sherpa altitude adaptation The expression and significance of IDH1 and p53 in osteosarcoma Potential therapeutic benefits of strategies directed to mitochondria.Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.Targeting histone lysine demethylases - progress, challenges, and the future 2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process.Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.

P2860

Q21129303-BECDD5E6-2615-44D2-8583-EE24061C267F Q21145799-3E578755-4A1D-462D-AEC1-E76D02C4F5CD Q21261429-C87D068A-104A-4807-B588-B27E6DC1E282 Q24294745-D69C746F-D5DD-4767-A010-B59CA1875C2A Q24600728-DAE82B4B-453D-4D0F-A711-AA9793A462A4 Q24630685-305CA534-5F8B-41BC-9779-F575293FC2B2 Q26775475-AAB8994F-A24B-48B5-80E6-6272942CCB79 Q26796203-18495586-E979-44FB-88CD-EA75F1B368E6 Q26849216-07123CA4-566D-4B47-B2C3-8DCCA00CECFD Q27002338-4D031289-1F0F-4350-8EF0-59F1C0A184C4 Q27022231-C7029CBD-BFA5-448E-878E-DCA09350DDA2 Q27023744-308EBC9F-EFC6-427F-A45E-8E6C7DD10FD5 Q27316863-9BCF0A91-1BE8-4B3F-85B8-FD7CFDFA6586 Q27692015-3A8E705C-8E07-4098-B5D0-41D32C5011F7 Q28074285-30BF2449-9B23-4ED6-A242-E8298E743D93 Q28082949-4FFC3B1D-E5D4-440F-A8A8-0DBD4D55B34F Q28085631-2A021C6B-4089-4C2A-81A7-5A465DF26D21 Q28282255-EE17754A-3A8A-4EC3-9310-BC1AF6E86EBE Q28385322-99988C85-CEB5-4683-AC67-4EE3711E243F Q28741513-6600B96C-9827-456F-A311-CFDD09B74DDF Q29396800-F7456862-4562-4C2B-9C0E-FCD98A4C69AF Q29619709-F696BF45-F7A4-4B1A-865C-3495945DE9B0 Q30431455-ACB32806-217C-49C7-B94C-126898FF3BA7 Q30845183-AEEE64B8-67E2-4C2C-A72E-8FBA4C0C7A99 Q31154376-1C58233D-0CE8-4A87-A49D-62D6EA685732 Q33292692-1C15DC8B-4CC7-4077-90FB-98D3F77D242F Q33590969-106CC3A9-2862-4A71-9368-523B205247B8 Q33608219-2D827AAF-8EDF-411E-97FB-74BF163C9412 Q33652731-D61622D1-8273-45DE-9AFB-9B077FE0B122 Q33723765-D8E5F20B-E369-4288-A1E5-BAC30015F966 Q33795007-95CA8717-D9A9-4975-B0A7-927194F3C162 Q33810317-D5BE4550-B6B8-43B3-88C9-44F4D1C79480 Q33864108-8DD2E539-2B4C-47D1-8584-00E9B6C6F323 Q34117168-FC07C21D-C4F0-44FF-A74E-1AADC1CABF21 Q34279708-D7BA2539-187B-43EB-8A6A-83733284FDEF Q34419977-78E99714-C50D-4835-A6DA-8D9AC645B5C5 Q34421279-81847DCD-BEA2-4295-914B-6538E17CC06F Q34482634-3AED0027-AC6C-4CCA-BB07-E646DC0464B7 Q34536966-A06CFCD3-0E8E-457B-A810-54F4486CF1A8 Q34566270-68B4883B-8834-43AA-B4D6-AB06D8C26A96

P2860

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

http://www.wikidata.org/entity/Q24683296

description

2007 nî lūn-bûn

@nan

2007 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Cell-permeating alpha-ketoglut ...... dehydrogenase-deficient cells

@ast

Cell-permeating alpha-ketoglut ...... dehydrogenase-deficient cells

@en

Cell-permeating alpha-ketoglut ...... dehydrogenase-deficient cells

@nl

type

label

Cell-permeating alpha-ketoglut ...... dehydrogenase-deficient cells

@ast

Cell-permeating alpha-ketoglut ...... dehydrogenase-deficient cells

@en

Cell-permeating alpha-ketoglut ...... dehydrogenase-deficient cells

@nl

prefLabel

Cell-permeating alpha-ketoglut ...... dehydrogenase-deficient cells

@ast

Cell-permeating alpha-ketoglut ...... dehydrogenase-deficient cells

@en

Cell-permeating alpha-ketoglut ...... dehydrogenase-deficient cells

@nl

P1433

Q24683296-28816CEC-9DE0-4B1F-89C7-78FE35B5B5CB

P1476

Q24683296-D3B6D8B5-74EB-47F6-9147-C8A02067EB72

P2093

Q24683296-2020C974-94E1-4C81-BCDF-35C6D236BB15

Q24683296-2DC7D089-C2B5-45CF-A0C9-890B4B571604

Q24683296-4E6A13CA-4939-4005-BF48-7345EE915C92

Q24683296-84E4DC83-FDB4-4911-87FC-BA3528CC737F

Q24683296-A969152F-994A-4F46-9440-868B00BE72DC

Q24683296-D0E02934-8B38-4B64-BD42-B6A8B0741B31

P2860

Q24683296-0A791E60-B7E3-4835-AD88-20AD4B9E40F1

Q24683296-1C6AC046-D642-4CD4-B49C-541FAFB1F361

Q24683296-1D665AD8-F4D6-4097-8E98-8D31CA0DB418

Q24683296-2C0EB5B0-B501-4432-B39F-76E9F74C8188

Q24683296-40913F38-970D-4AF5-8528-21A16E8A4B47

Q24683296-4EC0E023-C254-4784-838C-01AA8D76D1DF

Q24683296-4EC57E0E-A70C-4090-B82F-6B783BE88912

Q24683296-55936B4F-425E-45B6-9436-127F0C03AD4F

Q24683296-855D117A-9F6E-472B-8CB2-46FB169CC3E0

Q24683296-8C74CD3F-0476-4F96-B186-B74EDBD0CF37

P304

Q24683296-E4469861-D92F-4C42-A1A5-246077CE016B

P31

Q24683296-2EE00A9F-0D19-40B4-B5E7-4DB4A8CD6CA1

P3181

Q24683296-4837B913-278D-4CB6-8600-BC4C2C79536B

P356

Q24683296-0D13DC60-BED2-44F8-9F1C-E3BC7EE80578

P407

Q24683296-E0F32D04-5862-4072-8055-C7C9ED864715

P433

Q24683296-D955DC3D-9B12-465E-A580-EDDC37A450EE

P478

Q24683296-8071C4FA-E0B9-48E3-981C-70BBB0433E02

P50

Q24683296-448CE310-283D-40AB-B0BF-DBBE00A7A5E8

Q24683296-B3654B17-B84D-4F96-9131-014F01D73918

P577

Q24683296-5A8CAFB9-C872-4133-BD83-CE2F8A2CF52E

P5875

Q24683296-28A159BB-7C69-409D-88EB-AA8EFA7D125F

P698

Q24683296-141F04A3-6111-4F28-96A6-7C2F5C5E8976

P921

Q24683296-E430F0A5-46A4-453B-BEA3-305AA104025A

P932

Q24683296-BBE15B55-D1DC-45B6-BAFF-F72743984273

P3181

P356

P1433

Molecular and Cellular Biology

P1476

Cell-permeating alpha-ketoglut ...... dehydrogenase-deficient cells

@en

P2093

Casper M Frederiksen

http://www.w3.org/2001/XMLSchema#string

David G Watson

http://www.w3.org/2001/XMLSchema#string

Elaine D MacKenzie

http://www.w3.org/2001/XMLSchema#string

Lloyd J Payne

http://www.w3.org/2001/XMLSchema#string

Mary A Selak

http://www.w3.org/2001/XMLSchema#string

Stuart Crosby

http://www.w3.org/2001/XMLSchema#string

P2860

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas

Architecture of succinate dehydrogenase and reactive oxygen species generation

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

HIF-1 and tumor progression: pathophysiology and therapeutics

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

Mitochondrial tumour suppressors: a genetic and biochemical update

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

P304

3282-9

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2702264

http://www.w3.org/2001/XMLSchema#string

P356

10.1128/MCB.01927-06

http://www.w3.org/2001/XMLSchema#string

P407

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

27

http://www.w3.org/2001/XMLSchema#string

P50

Daniel A Tennant

P577

2007-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6481450

http://www.w3.org/2001/XMLSchema#string

P698

17325041

http://www.w3.org/2001/XMLSchema#string

P921

P932

1899954

http://www.w3.org/2001/XMLSchema#string