Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies. - Test2 - elhamkhani - TriplyDB

Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.

Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.

http://www.wikidata.org/entity/Q34578265

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Genetics of myeloproliferative neoplasms Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases Myeloid malignancies: mutations, models and management Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1 Recent advances in diagnosis, molecular pathology and therapy of chronic myelomonocytic leukaemia Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders Use of single nucleotide polymorphism array technology to improve the identification of chromosomal lesions in leukemia Clinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasms Activating CBL mutations are associated with a distinct MDS/MPN phenotype.Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias.Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia.Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia Cbl and human myeloid neoplasms: the Cbl oncogene comes of age.Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype.Identification of heptapeptides interacting with IFN-α-sensitive CML cells.Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism Current outlook on molecular pathogenesis and treatment of myeloproliferative neoplasms.Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis.Myeloproliferative neoplasms: from JAK2 mutations discovery to JAK2 inhibitor therapies.Molecular genetics of chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia.Cancer in Noonan, Costello, cardiofaciocutaneous and LEOPARD syndromes.Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies Complex patterns of chromosome 11 aberrations in myeloid malignancies target CBL, MLL, DDB1 and LMO2.CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.Ubiquitin carboxyl-terminal esterase L1 (UCHL1) S18Y polymorphism in patients with cataracts.Dasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice.Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.Molecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment.A high occurrence of acquisition and/or expansion of C-CBL mutant clones in the progression of high-risk myelodysplastic syndrome to acute myeloid leukemia Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide.Novel somatic and germline mutations in intracranial germ cell tumours.Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer.Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia Using an exon microarray to identify a global profile of gene expression and alternative splicing in K562 cells exposed to sodium valproate.UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.High c-Cbl expression in gliomas is associated with tumor progression and poor prognosis

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Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.

http://www.wikidata.org/entity/Q34578265

description

2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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name

Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.

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Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.

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Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.

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type

label

Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.

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Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.

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Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.

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prefLabel

Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.

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Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.

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Mutations of e3 ubiquitin liga ...... esion in myeloid malignancies.

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JCO.2009.23.7503

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Journal of Clinical Oncology

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Mutations of e3 ubiquitin liga ...... lesion in myeloid malignancies

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Andrew Dunbar

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Christine O'Keefe

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Eric Hsi

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Hadrian Szpurka

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Heather Cazzolli

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Hideki Makishima

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Hideki Muramatsu

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Jaroslaw P Maciejewski

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Jungwon Huh

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Michael A McDevitt

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P2860

Genomic disorders: molecular mechanisms for rearrangements and conveyed phenotypes

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif

Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.

Detection of large-scale variation in the human genome

The Cbl interactome and its functions

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

A gain-of-function mutation of JAK2 in myeloproliferative disorders

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

SNP array karyotyping allows for the detection of uniparental disomy and cryptic chromosomal abnormalities in MDS/MPD-U and MPD.

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10.1200/JCO.2009.23.7503

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36

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