Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast.
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The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instabilityDNA mismatch repair: molecular mechanism, cancer, and ageingEvidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutationsThe exceptionally high rate of spontaneous mutations in the polymerase delta proofreading exonuclease-deficient Saccharomyces cerevisiae strain starved for adenineReplicative DNA polymerase mutations in cancerAntimutator variants of DNA polymerasesThe multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domainsMismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.Replicative DNA polymerase δ but not ε proofreads errors in Cis and in TransEukaryotic genome instability in light of asymmetric DNA replicationDNA replication fidelity and cancerIn vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zetaGenome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminaseThe Rtt109 histone acetyltransferase facilitates error-free replication to prevent CAG/CTG repeat contractions.Mutator suppression and escape from replication error-induced extinction in yeastEXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiae.A DNA polymerase epsilon mutant that specifically causes +1 frameshift mutations within homonucleotide runs in yeast.A novel function of DNA polymerase zeta regulated by PCNA.Inverted Alu repeats unstable in yeast are excluded from the human genome.Volatility of Mutator Phenotypes at Single Cell ResolutionMechanisms of glycosylase induced genomic instabilityDNA polymerases δ and λ cooperate in repairing double-strand breaks by microhomology-mediated end-joining in Saccharomyces cerevisiaeRequirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae.Mutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae.Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.A common cancer-associated DNA polymerase ε mutation causes an exceptionally strong mutator phenotype, indicating fidelity defects distinct from loss of proofreading.Role of DNA polymerases in repeat-mediated genome instabilityHuman DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro.Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases.
P2860
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P2860
Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast.
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1999 nî lūn-bûn
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1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
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1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
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name
Genetic factors affecting the ...... n mutation avoidance in yeast.
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Genetic factors affecting the ...... n mutation avoidance in yeast.
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Genetic factors affecting the ...... n mutation avoidance in yeast.
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Genetic factors affecting the ...... n mutation avoidance in yeast.
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Genetic factors affecting the ...... n mutation avoidance in yeast.
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Genetic factors affecting the ...... n mutation avoidance in yeast.
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Genetic factors affecting the ...... n mutation avoidance in yeast.
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Genetic factors affecting the ...... n mutation avoidance in yeast.
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Genetic factors affecting the ...... n mutation avoidance in yeast.
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P2093
P2860
P1433
P1476
Genetic factors affecting the ...... on mutation avoidance in yeast
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P2093
Degtyareva NP
Resnick MA
P2860
P407
P577
1999-05-01T00:00:00Z