Analysis of HIV-1 replication block due to substitutions at F61 residue of reverse transcriptase reveals additional defects involving the RNase H function
about
RNase H activity: structure, specificity, and function in reverse transcriptionRibonuclease H: properties, substrate specificity and roles in retroviral reverse transcriptionSubstitution of alanine for tyrosine-64 in the fingers subdomain of M-MuLV reverse transcriptase impairs strand displacement synthesis and blocks viral replication in vivo.Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors".Preferred sequences within a defined cleavage window specify DNA 3' end-directed cleavages by retroviral RNases HMutation rates and intrinsic fidelity of retroviral reverse transcriptases.HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently.LEDGF/p75 Deficiency Increases Deletions at the HIV-1 cDNA Ends.Thermostable HIV-1 group O reverse transcriptase variants with the same fidelity as murine leukaemia virus reverse transcriptase.Discovery of a semi-synthesized cyclolignan as a potent HIV-1 non-nucleoside reverse transcriptase inhibitor.
P2860
Q24643032-191C9DE5-3C91-4C0A-B28E-829447E4ECDAQ24655903-76AC17DC-4AFF-4D7C-A6BB-DD3009429713Q36098110-726AA7BC-460D-401A-8224-FCEE0FB4274DQ36949351-7A24747D-CA71-4809-BCEF-63FD684FA030Q37431890-2EE06C97-F0BD-43E3-8616-63A5C0401AA6Q37945186-AB0DCC70-D608-43C9-B303-98FDF292365BQ39253058-81FB8E53-B992-40F9-BE1B-8F280CFAED44Q40038972-0B86028E-FA22-4ABE-8FBC-9466311FF338Q45367817-41E0242B-BED7-4CAC-985A-1B0EBE36D8ABQ47560158-8EBB4546-9E28-48B9-BD3E-331196007CBF
P2860
Analysis of HIV-1 replication block due to substitutions at F61 residue of reverse transcriptase reveals additional defects involving the RNase H function
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Analysis of HIV-1 replication ...... involving the RNase H function
@ast
Analysis of HIV-1 replication ...... involving the RNase H function
@en
Analysis of HIV-1 replication ...... involving the RNase H function
@nl
type
label
Analysis of HIV-1 replication ...... involving the RNase H function
@ast
Analysis of HIV-1 replication ...... involving the RNase H function
@en
Analysis of HIV-1 replication ...... involving the RNase H function
@nl
prefLabel
Analysis of HIV-1 replication ...... involving the RNase H function
@ast
Analysis of HIV-1 replication ...... involving the RNase H function
@en
Analysis of HIV-1 replication ...... involving the RNase H function
@nl
P2860
P356
P1476
Analysis of HIV-1 replication ...... involving the RNase H function
@en
P2093
Dibyakanti Mandal
Stuart F J Le Grice
P2860
P304
P356
10.1093/NAR/GKL360
P407
P577
2006-05-24T00:00:00Z