The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. - Test2 - elhamkhani - TriplyDB

The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival.

The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival.

http://www.wikidata.org/entity/Q34659420

about

Ectopic Expression of Testis Germ Cell Proteins in Cancer and Its Potential Role in Genomic Instability Exploring the developmental mechanisms underlying Wolf-Hirschhorn Syndrome: Evidence for defects in neural crest cell migration Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension.Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles Multiple cancer testis antigens function to support tumor cell mitotic fidelity.MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics.Mitotic catastrophe and cell death induced by depletion of centrosomal proteins.Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly.Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes.Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway.TACC3 is essential for EGF-mediated EMT in cervical cancer MoMuLV-ts-1: A Unique Mouse Model of Retrovirus-Induced Lymphoma Transmitted by Breast Milk.Novel functions of endocytic player clathrin in mitosis.TACC3 promotes stemness and is a potential therapeutic target in hepatocellular carcinoma.lin9 is required for mitosis and cell survival during early zebrafish development.Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).Mechanisms of Chromosome Congression during Mitosis.Defining the genomic landscape of head and neck cancers through next-generation sequencing.From global proteome profiling to single targeted molecules of follicular fluid and oocyte: contribution to embryo development and IVF outcome.PKCι depletion initiates mitotic slippage-induced senescence in glioblastoma A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells.Oncogenic FGFR3 gene fusions in bladder cancer.Regulation of paclitaxel activity by microtubule-associated proteins in cancer chemotherapy.The role of TACC3 in mitotic spindle organization.The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.FGFR3-TACC3 cancer gene fusions cause mitotic defects by removal of endogenous TACC3 from the mitotic spindle TACC3 protein regulates microtubule nucleation by affecting γ-tubulin ring complexes.The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.Repeats in transforming acidic coiled-coil (TACC) genes.GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms.Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions.TACC3 deregulates the DNA damage response and confers sensitivity to radiation and PARP inhibition.TACC3 transcriptionally upregulates E2F1 to promote cell growth and confer sensitivity to cisplatin in bladder cancer.Disruption of Tacc3 function leads to in vivo tumor regression.Pretreatment TACC3 expression in locally advanced rectal cancer decreases the response to neoadjuvant chemoradiotherapy

P2860

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P2860

The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival.

http://www.wikidata.org/entity/Q34659420

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2007 nî lūn-bûn

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2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2007 թվականի օգոստոսին հրատարակված գիտական հոդված

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2007年の論文

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The transforming acidic coiled ...... lignment and mitotic survival.

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The transforming acidic coiled ...... lignment and mitotic survival.

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The transforming acidic coiled ...... lignment and mitotic survival.

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The transforming acidic coiled ...... lignment and mitotic survival.

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The transforming acidic coiled ...... lignment and mitotic survival.

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The transforming acidic coiled ...... lignment and mitotic survival.

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The transforming acidic coiled ...... lignment and mitotic survival.

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The transforming acidic coiled ...... lignment and mitotic survival.

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The transforming acidic coiled ...... lignment and mitotic survival.

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Journal of Biological Chemistry

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The transforming acidic coiled ...... lignment and mitotic survival.

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P2093

Anja Kletke

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Bernd Nürnberg

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Frank Essmann

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Helmut Hanenberg

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Klaus Schulze-Osthoff

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Roland P Piekorz

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Wiebke Wetzel

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P2860

Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms

Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators

TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly

The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation.

The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis

AZU-1: a candidate breast tumor suppressor and biomarker for tumor progression

D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo

Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint.

The TACC domain identifies a family of centrosomal proteins that can interact with microtubules

The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells

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29273-29283

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10.1074/JBC.M704151200

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40

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282

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Leonid Schneider

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2007-08-05T00:00:00Z

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17675670

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