Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway.
about
MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formationSNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.Induced protein degradation: an emerging drug discovery paradigm.High expression of TACC3 in esophageal squamous cell carcinoma correlates with poor prognosis.In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary DisordersChemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathwayTargeted protein knockdown using small molecule degraders.Targeted Protein Degradation: from Chemical Biology to Drug Discovery.The role of TACC3 in mitotic spindle organization.Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.Clinicopathological and prognostic value of transforming acidic coiled-coil-containing protein 3 (TACC3) expression in soft tissue sarcomas.A look into centrosome abnormalities in colon cancer cells, how they arise and how they might be targeted therapeutically.Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules.Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugsPharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase
P2860
Q26991530-03143122-AB45-46D5-8B94-648277129678Q33738889-96EB088B-C695-40C2-AA1D-4855B03A23B1Q34545841-AA816365-94D0-4AD0-9F58-A260B0BE39D6Q35740091-4E8DFEB8-AFFB-4D16-9B6F-0DF5B92DAF3CQ36268420-69AF1675-9BF4-448F-9BFE-C63AB52C6DA4Q36301330-95F5DC4B-11D0-44C2-8876-9CBCAED24FAFQ36309724-343FD065-102A-45EB-A5D2-DC34CEFDEFA3Q39367115-3A57D240-C083-4744-8279-82F84F70F937Q39396984-3DC5EE26-1C43-4589-BAF0-4A63C82073B4Q39459238-FFFC2139-3BAC-4312-BDDE-77D00058FE32Q41247551-E589E275-DEA5-4DBE-9E53-0B19A3344A09Q45873447-79BC7ED4-530C-4494-A1EC-86226FF1F380Q45994976-B0C7EF4E-B490-4E3F-A727-67C788875904Q47413459-932759F5-506B-4132-B5E1-4EC17060CD8CQ52653329-613153FE-76E6-43F2-8A73-8222227A0334Q52901738-E383851E-07E3-47E8-852D-81A44478B235Q55043775-EB80FB1C-DCA4-47EB-882D-C20BF68A68AFQ58738119-9AF3B9D5-0E06-43D4-8C65-B4B914900656Q58756135-04D421DA-C813-41C5-B54F-A3EE8BECCC50
P2860
Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway.
description
2014 nî lūn-bûn
@nan
2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
name
Cancer cell death induced by n ...... ubiquitin-proteasome pathway.
@ast
Cancer cell death induced by n ...... ubiquitin-proteasome pathway.
@en
Cancer cell death induced by n ...... ubiquitin-proteasome pathway.
@nl
type
label
Cancer cell death induced by n ...... ubiquitin-proteasome pathway.
@ast
Cancer cell death induced by n ...... ubiquitin-proteasome pathway.
@en
Cancer cell death induced by n ...... ubiquitin-proteasome pathway.
@nl
prefLabel
Cancer cell death induced by n ...... ubiquitin-proteasome pathway.
@ast
Cancer cell death induced by n ...... ubiquitin-proteasome pathway.
@en
Cancer cell death induced by n ...... ubiquitin-proteasome pathway.
@nl
P2093
P2860
P356
P1476
Cancer cell death induced by n ...... ubiquitin-proteasome pathway.
@en
P2093
P2860
P2888
P356
10.1038/CDDIS.2014.471
P577
2014-11-06T00:00:00Z
P5875
P6179
1009865909