Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii.
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Recent advances in understanding apicomplexan parasitesPersistence of Toxoplasma gondii in the central nervous system: a fine-tuned balance between the parasite, the brain and the immune systemIdentification of the microsporidian Encephalitozoon cuniculi as a new target of the IFNγ-inducible IRG resistance systemStructure of the Toxoplasma gondii ROP18 Kinase Domain Reveals a Second Ligand Binding Pocket Required for Acute VirulencePathophysiological role of guanylate-binding proteins in gastrointestinal diseasesSecreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis?Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune CellsInterferon-induced guanylate-binding proteins in inflammasome activation and host defenseThe E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice.TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles.The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy.Toxoplasma gondii development of its replicative niche: in its host cell and beyond.Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination.Invariant NKT cells require autophagy to coordinate proliferation and survival signals during differentiation.Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection.Cutting Edge: IFN-γ Produced by Brain-Resident Cells Is Crucial To Control Cerebral Infection with Toxoplasma gondii.RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondiiA Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteinsK63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells.Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes.Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity.Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondiiIrgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation.Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse.Gamma interferon-induced guanylate binding protein 1 is a novel actin cytoskeleton remodeling factor.Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii.Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems.Interferon-inducible GTPases in cell autonomous and innate immunity.Immune Response: Intracellular pathogens under attackViral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases.Toxoplasma Effectors Targeting Host Signaling and Transcription.Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease.Quo vadis? Interferon-inducible GTPases go to their target membranes via the LC3-conjugation system of autophagy.Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against Toxoplasma gondii.Expression profiling of the GBP1 gene as a candidate gene for porcine reproductive and respiratory syndrome resistance.Towards vaccine against toxoplasmosis: evaluation of the immunogenic and protective activity of recombinant ROP5 and ROP18 Toxoplasma gondii proteins.The Rhoptry Pseudokinase ROP54 Modulates Toxoplasma gondii Virulence and Host GBP2 Loading.Processing and secretion of guanylate binding protein-1 depend on inflammatory caspase activity.
P2860
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P2860
Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii.
description
2013 nî lūn-bûn
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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2013 թվականի ապրիլին հրատարակված գիտական հոդված
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2013年の論文
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2013年学术文章
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name
Guanylate-binding protein 1 (G ...... ity against Toxoplasma gondii.
@ast
Guanylate-binding protein 1 (G ...... ity against Toxoplasma gondii.
@en
Guanylate-binding protein 1
@nl
type
label
Guanylate-binding protein 1 (G ...... ity against Toxoplasma gondii.
@ast
Guanylate-binding protein 1 (G ...... ity against Toxoplasma gondii.
@en
Guanylate-binding protein 1
@nl
prefLabel
Guanylate-binding protein 1 (G ...... ity against Toxoplasma gondii.
@ast
Guanylate-binding protein 1 (G ...... ity against Toxoplasma gondii.
@en
Guanylate-binding protein 1
@nl
P2093
P2860
P50
P1433
P1476
Guanylate-binding protein 1 (G ...... ity against Toxoplasma gondii.
@en
P2093
Daniel Degrandi
John D Macmicking
Sarah J Fentress
Wandy L Beatty
P2860
P304
P356
10.1371/JOURNAL.PPAT.1003320
P577
2013-04-25T00:00:00Z