Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. - Test2 - elhamkhani - TriplyDB

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

http://www.wikidata.org/entity/Q34723434

about

Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complex The many roles of histone deacetylases in development and physiology: implications for disease and therapy Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies.Induction of human gamma globin gene expression by histone deacetylase inhibitors Induction of fetal hemoglobin by propionic and butyric acid derivatives: correlations between chemical structure and potency of Hb F induction Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury.Butyrate increases the efficiency of translation of gamma-globin mRNA.CTD small phosphatase like 2 (CTDSPL2) can increase ε- and γ-globin gene expression in K562 cells and CD34+ cells derived from umbilical cord blood.Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation.The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice.Quantitative analysis of globin gene induction in single human erythroleukemic cells.Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.Mechanism for fetal globin gene expression: role of the soluble guanylate cyclase-cGMP-dependent protein kinase pathway.Design of embedded chimeric peptide nucleic acids that efficiently enter and accurately reactivate gene expression in vivo Identification and characterization of mechanistically distinct inducers of gamma-globin transcription Enhancement of growth and survival and alterations in Bcl-family proteins in beta-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives Induction of fetal globin in beta-thalassemia: Cellular obstacles and molecular progress.Identification of novel small-molecule inducers of fetal hemoglobin using pharmacophore and 'PSEUDO' receptor models.Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo.Fetal hemoglobin in sickle cell anemia Pharmacotherapy in sickle cell disease--state of the art and future prospects Sickle cell disease: old discoveries, new concepts, and future promise.Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex.The TNFalpha locus is altered in monocytes from patients with systemic lupus erythematosus.Gum Arabic as fetal hemoglobin inducing agent in sickle cell anemia; in vivo study.FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors.EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.Regulation of human fetal hemoglobin: new players, new complexities.Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin.Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma.Epigenetic analysis of the human alpha- and beta-globin gene clusters.Butyrate histone deacetylase inhibitors.Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease.Hydroxyurea for children with sickle cell disease Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway.Histone deacetylase inhibitors and hemoglobin F induction in beta-thalassemia Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation.Current management of sickle cell anemia.

P2860

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P2860

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

http://www.wikidata.org/entity/Q34723434

description

1999 nî lūn-bûn

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1999 թուականի Մարտին հրատարակուած գիտական յօդուած

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1999 թվականի մարտին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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name

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

@ast

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

@en

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

@nl

type

label

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

@ast

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

@en

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

@nl

prefLabel

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

@ast

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

@en

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

@nl

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Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

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D V Faller

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E Wright

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G F Atweh

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G Stamatoyannopoulos

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L McMahon

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S P Perrine

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S Wallenstein

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P2860

Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression

Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate

A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression

Butyrate infusions in the ovine fetus delay the biologic clock for globin gene switching.

Human globin gene transcription in injected Xenopus oocytes: enhancement by sodium butyrate.

A specific chemical difference between the globins of normal human and sickle-cell anaemia haemoglobin.

Molecular analysis of sodium butyrate-induced growth arrest.

Augmentation by erythropoietin of the fetal-hemoglobin response to hydroxyurea in sickle cell disease.

Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia.

Therapeutic approaches to hemoglobin switching in treatment of hemoglobinopathies.

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