Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.
about
The role of metabotropic glutamate receptor 5 on the stromal cell-derived factor-1/CXCR4 system in oral cancerGenetic models of sensorimotor gating: relevance to neuropsychiatric disorders.Location-dependent signaling of the group 1 metabotropic glutamate receptor mGlu5.CB1 augments mGluR5 function in medial prefrontal cortical neurons to inhibit amygdala hyperactivity in an arthritis pain model.The role of metabotropic glutamate receptor 5 in the pathogenesis of mood disorders and addiction: combining preclinical evidence with human Positron Emission Tomography (PET) studies.The mGluR5 Positive Allosteric Modulator CDPPB Does Not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in RatsModulation of pyramidal cell output in the medial prefrontal cortex by mGluR5 interacting with CB1.Reduced metabotropic glutamate receptor 5 in the Flinders Sensitive Line of rats, an animal model of depression: an autoradiographic study.Studies of the metabotropic glutamate receptor 5 radioligand [¹¹C]ABP688 with N-acetylcysteine challenge in rhesus monkeys.Metabotropic glutamate receptor 5 negative modulation in phase I clinical trial: potential impact of circadian rhythm on the neuropsychiatric adverse reactions-do hallucinations matter?Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus.Glutamate drugs and pharmacogenetics of OCD: a pathway-based exploratory approach.Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research.The mGluR5 positive allosteric modulator CDPPB inhibits SO₂-induced protein radical formation and mitochondrial dysfunction through activation of Akt in mouse hippocampal HT22 cells.Microscopic visualization of metabotropic glutamate receptors on the surface of living cells using bifunctional magnetic resonance imaging probesComparative in vitro studies of MR imaging probes for metabotropic glutamate subtype-5 receptor targeting.Acute inhibition of mGluR5 disrupts behavioral flexibility.Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies.Spatial Learning Requires mGlu5 Signalling in the Dorsal Hippocampus.Pharmacological enhancement of mGluR5 facilitates contextual fear memory extinction.mGlu5 Receptor Functional Interactions and AddictionPET imaging of metabotropic glutamate receptor subtype 5 (mGluR5).Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.Selective Blockade of the Metabotropic Glutamate Receptor mGluR5 Protects Mouse Livers in In Vitro and Ex Vivo Models of Ischemia Reperfusion Injury.Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidine.Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions in mice.Triple-addition assay protocols for detecting and characterizing modulators of seven-transmembrane receptors.Targeting metabotropic glutamate receptors as a new strategy against levodopa-induced dyskinesia in Parkinson's disease?Functional Comparison of Neuronal Cells Differentiated from Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells under Different Oxygen and Medium Conditions.Neuregulin 1-induced AKT and ERK phosphorylation in patients with fragile X syndrome (FXS) and intellectual disability associated with obstetric complications.Age-Related Declines in Prefrontal Cortical Expression of Metabotropic Glutamate Receptors that Support Working Memory.Biphasic modulation of NMDA receptor function by metabotropic glutamate receptors
P2860
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P2860
Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Positive allosteric modulators ...... he treatment of CNS disorders.
@ast
Positive allosteric modulators ...... he treatment of CNS disorders.
@en
Positive allosteric modulators of type 5 metabotropic glutamate receptors
@nl
type
label
Positive allosteric modulators ...... he treatment of CNS disorders.
@ast
Positive allosteric modulators ...... he treatment of CNS disorders.
@en
Positive allosteric modulators of type 5 metabotropic glutamate receptors
@nl
prefLabel
Positive allosteric modulators ...... he treatment of CNS disorders.
@ast
Positive allosteric modulators ...... he treatment of CNS disorders.
@en
Positive allosteric modulators of type 5 metabotropic glutamate receptors
@nl
P2860
P921
P1433
P1476
Positive allosteric modulators ...... the treatment of CNS disorders
@en
P2093
Richard M Cleva
P2860
P304
P356
10.3390/MOLECULES16032097
P407
P5008
P577
2011-03-02T00:00:00Z