Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273
about
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology.Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening.Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryProgress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5)."Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.Metabotropic glutamate receptor 5-positive allosteric modulators for the treatment of schizophrenia (2004-2012).Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTSDiscovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype.Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists.Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines.Metabotropic glutamate receptor 5 - a promising target in drug development and neuroimaging.Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold.Acyl-2-aminobenzimidazoles: a novel class of neuroprotective agents targeting mGluR5Cyclopropyl-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5.Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity.Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning.Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants.
P2860
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P2860
Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Synthesis, SAR and unanticipat ...... luR5 ago-potentiator ADX-47273
@ast
Synthesis, SAR and unanticipat ...... luR5 ago-potentiator ADX-47273
@en
Synthesis, SAR and unanticipat ...... luR5 ago-potentiator ADX-47273
@nl
type
label
Synthesis, SAR and unanticipat ...... luR5 ago-potentiator ADX-47273
@ast
Synthesis, SAR and unanticipat ...... luR5 ago-potentiator ADX-47273
@en
Synthesis, SAR and unanticipat ...... luR5 ago-potentiator ADX-47273
@nl
prefLabel
Synthesis, SAR and unanticipat ...... luR5 ago-potentiator ADX-47273
@ast
Synthesis, SAR and unanticipat ...... luR5 ago-potentiator ADX-47273
@en
Synthesis, SAR and unanticipat ...... luR5 ago-potentiator ADX-47273
@nl
P2093
P2860
P50
P356
P1433
P1476
Synthesis, SAR and unanticipat ...... luR5 ago-potentiator ADX-47273
@en
P2093
Alice L Rodriguez
Darren W Engers
Daryl Venable
Gary A Sulikowski
Oluwatomi Oluwatola
Richard Williams
P2860
P304
P356
10.1002/CMDC.200800357
P407
P577
2009-04-01T00:00:00Z