Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy.
about
The neurology of mTORHarnessing the power of metabolism for seizure prevention: focus on dietary treatmentsFinding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic targetSpatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatmentRapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injuryHyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in miceMolecular mechanisms of epilepsyMapping the spatio-temporal pattern of the mammalian target of rapamycin (mTOR) activation in temporal lobe epilepsyA pulse rapamycin therapy for infantile spasms and associated cognitive decline.Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy.Mammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures.The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments.Hippocampal neuropathology of domoic acid-induced epilepsy in California sea lions (Zalophus californianus).Hippocampal granule cell pathology in epilepsy - a possible structural basis for comorbidities of epilepsy?Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsyPrevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization.The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway.Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction.Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid.The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice.Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy.Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling.Expansion of the dentate mossy fiber-CA3 projection in the brain-derived neurotrophic factor-enriched mouse hippocampus.PTEN deletion from adult-generated dentate granule cells disrupts granule cell mossy fiber axon structure.Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive declinemTOR signaling in epilepsy: insights from malformations of cortical developmentRapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy.Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice.Surviving mossy cells enlarge and receive more excitatory synaptic input in a mouse model of temporal lobe epilepsy.Is there a critical period for mossy fiber sprouting in a mouse model of temporal lobe epilepsy?Progress in cell grafting therapy for temporal lobe epilepsy.Epilepsy as a neurodevelopmental disorder.Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy.Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats.Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy."Untangling" Alzheimer's disease and epilepsy.Rapamycin has age-, treatment paradigm-, and model-specific anticonvulsant effects and modulates neuropeptide Y expression in rats.Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures.Brain inflammation as a biomarker in epilepsy.
P2860
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P2860
Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy.
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Rapamycin suppresses mossy fib ...... del of temporal lobe epilepsy.
@ast
Rapamycin suppresses mossy fib ...... del of temporal lobe epilepsy.
@en
Rapamycin suppresses mossy fib ...... del of temporal lobe epilepsy.
@nl
type
label
Rapamycin suppresses mossy fib ...... del of temporal lobe epilepsy.
@ast
Rapamycin suppresses mossy fib ...... del of temporal lobe epilepsy.
@en
Rapamycin suppresses mossy fib ...... del of temporal lobe epilepsy.
@nl
prefLabel
Rapamycin suppresses mossy fib ...... del of temporal lobe epilepsy.
@ast
Rapamycin suppresses mossy fib ...... del of temporal lobe epilepsy.
@en
Rapamycin suppresses mossy fib ...... del of temporal lobe epilepsy.
@nl
P2860
P1476
Rapamycin suppresses mossy fib ...... del of temporal lobe epilepsy.
@en
P2093
Felicia H Lew
Paul S Buckmaster
P2860
P304
P356
10.1523/JNEUROSCI.4852-10.2011
P407
P577
2011-02-01T00:00:00Z