CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
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Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alphaCrystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolutionPharmacogenetics as a tool to tailor antiretroviral therapy: A reviewSteroid receptor coactivators: servants and masters for control of systems metabolismInvestigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzymeA Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational StatesStructural and Thermodynamic Basis of (+)-α-Pinene Binding to Human Cytochrome P450 2B6Insights into CYP2B6-mediated drug-drug interactionsCytochrome P450-mediated drug metabolism in the brainStructural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.Genetic variation in the CYP2B6 gene is related to circulating 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study.PharmGKB summary: ifosfamide pathways, pharmacokinetics and pharmacodynamics.Expression of P450 and nuclear receptors in normal and end-stage Chinese livers.Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and responseEfavirenz primary and secondary metabolism in vitro and in vivo: identification of novel metabolic pathways and cytochrome P450 2A6 as the principal catalyst of efavirenz 7-hydroxylationAbsorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse.Synergistically enhanced CYP2B6 inducibility between a polymorphic mutation in CYP2B6 promoter and pregnane X receptor activation.DNA and histone deacetylases as targets for neuroblastoma treatment.Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor.Cytochrome P450 single nucleotide polymorphisms in an indigenous Tanzanian population: a concern about the metabolism of artemisinin-based combinations.Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium FerulateCharacterization of CYP2B6 in a CYP2B6-humanized mouse model: inducibility in the liver by phenobarbital and dexamethasone and role in nicotine metabolism in vivoIntegration of population pharmacokinetics and pharmacogenetics: an aid to optimal nevirapine dose selection in HIV-infected individuals.The G⁵¹⁶T CYP2B6 germline polymorphism affects the risk of acute myeloid leukemia and is associated with specific chromosomal abnormalitiesPolymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase cRequired propofol dose for anesthesia and time to emerge are affected by the use of antiepileptics: prospective cohort study.Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison.Thr302 is the site for the covalent modification of human cytochrome P450 2B6 leading to mechanism-based inactivation by tert-butylphenylacetyleneComplex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir.Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor.Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.Differences in Methadone Metabolism by CYP2B6 VariantsTrapping of cis-2-butene-1,4-dial to measure furan metabolism in human liver microsomes by cytochrome P450 enzymesComparative De Novo Transcriptome Analysis of Fertilized Ovules in Xanthoceras sorbifolium Uncovered a Pool of Genes Expressed Specifically or Preferentially in the Selfed Ovule That Are Potentially Involved in Late-Acting Self-Incompatibility.Transcriptional Regulation of CYP2B6 Expression by Hepatocyte Nuclear Factor 3β in Human Liver Cells.Generation and characterization of a CYP2A13/2B6/2F1-transgenic mouse modelEstradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy.
P2860
Q21003928-D99CD95C-11F1-4354-8743-93E0A7A56B82Q24294558-546121FD-7C8D-4F39-BEA5-FB639A73C5E4Q26797938-B1052406-0532-4D1F-8D88-7D7D6177804CQ26825815-A4FD53E5-6E95-45C9-A0C5-C79AEC9BAE16Q27675363-8A60B436-7F09-482F-85C3-C6663C51CA73Q27677947-F4381AF2-27C8-44B8-BB05-6B9E8B464166Q27678713-503EA77C-572B-4957-B37C-DAE2A8264A02Q28078857-88C417DF-57BB-4750-B640-022417E0BF11Q28397217-B460BC28-7A35-4D35-BA4B-6B9414847907Q30396630-6D6E0113-1BC3-45E6-8643-A9950CCA8745Q33574862-FFFCA18D-53BD-415F-9167-470793AD50B7Q33591401-FE622113-885A-42E6-A9E7-4A9C2F8D3BE3Q33626302-E76F594C-736C-4D76-A3BB-E72B3DA7F0A5Q33855506-1E782023-D612-4735-8059-FD17FD3A4FDFQ33887136-6BFDBB66-226F-45EE-A275-DB894F256973Q33903933-BE2C9B95-152C-4F67-B0B3-DE1E1EF68CD6Q34015667-495971E5-4169-4F58-8E76-809B49E876FBQ34165511-EC801651-35D5-4162-A344-E4E6CB670417Q34310059-16E00912-2665-4E35-9D36-918E4448AB3FQ34320121-77645017-C383-4CA1-A5F0-D442BB541384Q34325249-94DA533D-0133-4B30-ADC9-210288049339Q34345924-F54E8970-1659-42EE-B7A0-DD2B2FEABE18Q34491448-516DA665-4C53-41A2-BD25-3A1F52FB6ACDQ34804191-38CCF32A-79DB-4BAC-A269-7DDC6650E11DQ34946016-5C6B1DCF-23FB-4D70-B577-13B74F153AD3Q34975110-5A46F93A-7893-4351-B9BD-518335970133Q35106387-3D8F3A9B-CA68-4E34-958F-C83689D695EEQ35188159-72F2C36E-0464-4199-AEE2-6E1FC07932E2Q35191123-D3176D97-CA0F-4B57-BF89-A7A1627EBE9EQ35198035-76B4781D-6AD9-49E7-9AB8-4103565FE30BQ35579527-2BF4C4FD-28F1-454D-BAFB-4032C90D65DBQ35579558-4653918C-23FF-4007-926C-7D847D51E8CCQ35627428-BCEABCCA-6E8C-4CC3-8857-8D364F5F5B21Q35685373-42F71501-4D0D-4615-9107-49F1D760B6B6Q35745266-B01D9D0C-3964-49E5-AC23-37744EEBFC0CQ35776642-A58B54BD-5F66-4B2F-B0F6-32DDA1828E2DQ35814515-3EAF943F-411C-4E5B-BF5E-550D60EE047AQ35941376-359A0700-E559-41E5-949C-C3494A79B30BQ35996452-DDA2E9A6-7AEA-446C-8373-FC8DEA87AFE7Q36037547-5BB84A4E-3150-45DB-974F-2A49E4AB9ED1
P2860
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
@ast
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
@en
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
@nl
type
label
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
@ast
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
@en
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
@nl
prefLabel
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
@ast
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
@en
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
@nl
P2860
P1476
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme
@en
P2093
Hongbing Wang
Leslie M Tompkins
P2860
P304
P356
10.2174/138920008785821710
P407
P577
2008-09-01T00:00:00Z