The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway - Test2 - elhamkhani - TriplyDB

The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway

The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway

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Targeting DNA topoisomerase II in cancer chemotherapy Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells Collision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5' Adducts The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex - a potentially new drug target Replication-dependent and transcription-dependent mechanisms of DNA double-strand break induction by the topoisomerase 2-targeting drug etoposide Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death The SUMO pathway is required for selective degradation of DNA topoisomerase IIbeta induced by a catalytic inhibitor ICRF-193(1)Topoisomerase IIalpha maintains genomic stability through decatenation G(2) checkpoint signaling Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells Dynamics of double strand breaks and chromosomal translocations Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM.All tangled up: how cells direct, manage and exploit topoisomerase function.Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons DNA double-strand breaks with 5' adducts are efficiently channeled to the DNA2-mediated resection pathway.Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis.NPM and BRG1 Mediate Transcriptional Resistance to Retinoic Acid in Acute Promyelocytic Leukemia Topoisomerase II Inhibitors Can Enhance Baculovirus-Mediated Gene Expression in Mammalian Cells through the DNA Damage Response The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells 3EZ,20Ac-ingenol, a catalytic inhibitor of topoisomerases, downregulates p-Akt and induces DSBs and apoptosis of DT40 cells.SUMO modification of DNA topoisomerase II: trying to get a CENse of it all Human multiple myeloma cells are sensitized to topoisomerase II inhibitors by CRM1 inhibition.Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae.Role of topoisomerase IIbeta in the expression of developmentally regulated genes.Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II.Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases.Topoisomerase IIalpha-dependent induction of a persistent DNA damage response in response to transient etoposide exposure.Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide.Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193: implications for the repair of topoisomerase II-mediated DNA damage.Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint.The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped topoisomerase II-DNA-cleavable complexes.Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry.Gene expression profiles in rat liver slices exposed to hepatocarcinogenic enzyme inducers, peroxisome proliferators, and 17alpha-ethinylestradiol.STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion.

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P2860

The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway

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2003 nî lūn-bûn

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2003 թուականի Մարտին հրատարակուած գիտական յօդուած

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2003 թվականի մարտին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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The topoisomerase IIbeta circu ...... gnals a 26S proteasome pathway

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The topoisomerase IIbeta circu ...... gnals a 26S proteasome pathway

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The topoisomerase IIbeta circu ...... gnals a 26S proteasome pathway

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Proceedings of the National Academy of Sciences of the United States of America

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The topoisomerase IIbeta circu ...... gnals a 26S proteasome pathway

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Chun-Yuan Ting

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Hai Xiao

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Jaulang Hwang

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Nai Zhou

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Shyamal D Desai

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Yong Mao

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P2860

Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24

The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polymerase II.

SUMO-1 conjugation to human DNA topoisomerase II isozymes

Factors regulating the transcriptional elongation activity of RNA polymerase II

Induction of apoptosis by dexrazoxane (ICRF-187) through caspases in the absence of c-jun expression and c-Jun NH2-terminal kinase 1 (JNK1) activation in VM-26-resistant CEM cells

DNA topoisomerase IIbeta and neural development

Co-localization of chicken DNA topoisomerase IIalpha, but not beta, with sites of DNA replication and possible involvement of a C-terminal region of alpha through its binding to PCNA.

The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells.

Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

The 26S proteasome: ubiquitin-mediated proteolysis in the tunnel.

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3239-3244

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10863479

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