Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation
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Research resource: Haploinsufficiency of receptor activity-modifying protein-2 (RAMP2) causes reduced fertility, hyperprolactinemia, skeletal abnormalities, and endocrine dysfunction in miceHomozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumorElusive liver factor that causes pancreatic α cell hyperplasia: A review of literatureDisruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice.The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreasPancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and massMice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cellsN-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathwayPancreatic neuroendocrine tumors in glucagon receptor-deficient mice.Animal models for small for gestational age and fetal programming of adult disease.Reducing plasma membrane sphingomyelin increases insulin sensitivity.Fertility and pregnancy-associated ß-cell proliferation in mice deficient in proglucagon-derived peptidesTransdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms.Shared effects of genetic and intrauterine and perinatal environment on the development of metabolic syndromeNovel insight into glucagon receptor action: lessons from knockout and transgenic mouse models.Effects of genetics and in utero diet on murine pancreatic development.Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signaling.Fetal adrenal demedullation lowers circulating norepinephrine and attenuates growth restriction but not reduction of endocrine cell mass in an ovine model of intrauterine growth restrictionGlucagon is essential for alpha cell transdifferentiation and beta cell neogenesis.Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult miceHypoglycemia, hyperglucagonemia, and fetoplacental defects in glucagon receptor knockout mice: a role for glucagon action in pregnancy maintenance.Regulation of mouse intestinal L cell progenitors proliferation by the glucagon family of peptides.Investigating endogenous peptides and peptidases using peptidomicsSelective expression of CYP2A13 in human pancreatic α-islet cells.Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosisGlucagon regulates its own synthesis by autocrine signaling.Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promiseIntra-islet glucagon secretion and action in the regulation of glucose homeostasis.Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor.Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.Insulin and glucagon levels of umbilical cord blood in appropriate for gestational age - preterm infants with or without postnatal hypoglycemiaIncretin action in the pancreas: potential promise, possible perils, and pathological pitfalls.Insulin signaling in alpha cells modulates glucagon secretion in vivo.Current insights and new perspectives on the roles of hyperglucagonemia in non-insulin-dependent type 2 diabetes.Oxyntomodulin increases intrinsic heart rate through the glucagon receptor.Differential expression of glucagon and glucagon-like peptide 1 receptors in mouse pancreatic alpha and beta cells in two models of alpha cell hyperplasia.Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes.Long-term hyperglucagonaemia induces early metabolic and renal phenotypes of Type 2 diabetes in mice.Pancreas cell fate.α-cell role in β-cell generation and regeneration.
P2860
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P2860
Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Ablation of the glucagon recep ...... let development and maturation
@ast
Ablation of the glucagon recep ...... let development and maturation
@en
Ablation of the glucagon recep ...... let development and maturation
@nl
type
label
Ablation of the glucagon recep ...... let development and maturation
@ast
Ablation of the glucagon recep ...... let development and maturation
@en
Ablation of the glucagon recep ...... let development and maturation
@nl
prefLabel
Ablation of the glucagon recep ...... let development and maturation
@ast
Ablation of the glucagon recep ...... let development and maturation
@en
Ablation of the glucagon recep ...... let development and maturation
@nl
P2093
P2860
P356
P1433
P1476
Ablation of the glucagon recep ...... let development and maturation
@en
P2093
Gladys Teitelman
Lingguang Cui
Mamdouh H Kedees
Maureen J Charron
Morris Nejathaim
Patricia M Vuguin
Richard W Gelling
Yelena Guz
P2860
P304
P356
10.1210/EN.2005-1410
P407
P577
2006-04-20T00:00:00Z