The MafA transcription factor appears to be responsible for tissue-specific expression of insulin - Test2 - elhamkhani - TriplyDB

The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

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Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression MafB is required for islet beta cell maturation FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus Generation of β cells from human pluripotent stem cells: are we there yet?Derivation of insulin-producing beta-cells from human pluripotent stem cells Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion Role of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expression Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development Precursor cells in mouse islets generate new beta-cells in vivo during aging and after islet injury.The MafA transcription factor becomes essential to islet β-cells soon after birth.Phosphorylation within the MafA N terminus regulates C-terminal dimerization and DNA binding.MafA is a key regulator of glucose-stimulated insulin secretion.Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes.The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression.Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.Direct lineage conversions: unnatural but useful?Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation Novel insight into glucagon receptor action: lessons from knockout and transgenic mouse models.Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3.Transcriptional factors, Mafs and their biological roles Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets.Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.MafA and MafB regulate genes critical to beta-cells in a unique temporal manner Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes.TGFβ Pathway Inhibition Redifferentiates Human Pancreatic Islet β Cells Expanded In Vitro Glucose induces MafA expression in pancreatic beta cell lines via the hexosamine biosynthetic pathway.Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells.β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.Hnf1α (MODY3) regulates β-cell-enriched MafA transcription factor expression.Minireview: Directed Differentiation and Encapsulation of Islet β-Cells-Recent Advances and Future Considerations.Inhibition of Small Maf Function in Pancreatic β-Cells Improves Glucose Tolerance Through the Enhancement of Insulin Gene Transcription and Insulin Secretion.The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.

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The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

http://www.wikidata.org/entity/Q24626092

description

2004 nî lūn-bûn

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2004 թուականի Մարտին հրատարակուած գիտական յօդուած

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2004 թվականի մարտին հրատարակված գիտական հոդված

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2004年の論文

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The MafA transcription factor ...... specific expression of insulin

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The MafA transcription factor ...... specific expression of insulin

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The MafA transcription factor ...... specific expression of insulin

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The MafA transcription factor ...... specific expression of insulin

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The MafA transcription factor ...... specific expression of insulin

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The MafA transcription factor ...... specific expression of insulin

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The MafA transcription factor ...... specific expression of insulin

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The MafA transcription factor ...... specific expression of insulin

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The MafA transcription factor ...... specific expression of insulin

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Proceedings of the National Academy of Sciences of the United States of America

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The MafA transcription factor ...... specific expression of insulin

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P2093

Anna Means

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Eva Henderson

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Isabella Artner

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Maike Sander

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Roland Stein

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Taka-aki Matsuoka

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P2860

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

PAX6 mutation as a genetic factor common to aniridia and glucose intolerance

MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1)

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

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