PIKfyve regulates the endosomal localization of CpG oligodeoxynucleotides to elicit TLR9-dependent cellular responses - Test2 - elhamkhani - TriplyDB

PIKfyve regulates the endosomal localization of CpG oligodeoxynucleotides to elicit TLR9-dependent cellular responses

PIKfyve regulates the endosomal localization of CpG oligodeoxynucleotides to elicit TLR9-dependent cellular responses

http://www.wikidata.org/entity/Q34989470

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The Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole.Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activity CpG-oligodeoxynucleotides suppress the proliferation of A549 lung adenocarcinoma cells via toll-like receptor 9 signaling and upregulation of Runt-related transcription factor 3 expression.IRAP+ endosomes restrict TLR9 activation and signaling.Toll-Like Receptors and Tissue Remodeling: The Pro/Cons Recent Findings.PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages.TLR9 is required for MAPK/NF-κB activation but does not cooperate with TLR2 or TLR6 to induce host resistance to Brucella abortus.Snapin promotes HIV-1 transmission from dendritic cells by dampening TLR8 signaling.

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P2860

PIKfyve regulates the endosomal localization of CpG oligodeoxynucleotides to elicit TLR9-dependent cellular responses

http://www.wikidata.org/entity/Q34989470

description

2013 nî lūn-bûn

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2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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PIKfyve regulates the endosoma ...... 9-dependent cellular responses

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PIKfyve regulates the endosoma ...... 9-dependent cellular responses

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PIKfyve regulates the endosoma ...... 9-dependent cellular responses

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PIKfyve regulates the endosoma ...... 9-dependent cellular responses

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PIKfyve regulates the endosoma ...... 9-dependent cellular responses

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PIKfyve regulates the endosoma ...... 9-dependent cellular responses

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PIKfyve regulates the endosoma ...... 9-dependent cellular responses

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PIKfyve regulates the endosoma ...... 9-dependent cellular responses

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PIKfyve regulates the endosoma ...... 9-dependent cellular responses

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JOURNAL.PONE.0073894

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PIKfyve regulates the endosoma ...... 9-dependent cellular responses

@en

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Kaoru Hazeki

http://www.w3.org/2001/XMLSchema#string

Kiyomi Nigorikawa

http://www.w3.org/2001/XMLSchema#string

Masami Uehara

http://www.w3.org/2001/XMLSchema#string

Osamu Hazeki

http://www.w3.org/2001/XMLSchema#string

P2860

The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.

The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice

Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella.

A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.

PIKfyve: Partners, significance, debates and paradoxes

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity.

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e73894

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scholarly article

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10.1371/JOURNAL.PONE.0073894

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24040108

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3767827

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