SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA. - Test2 - elhamkhani - TriplyDB

SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA.

SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA.

http://www.wikidata.org/entity/Q35005149

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Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells.Uncapped 5' ends of mRNAs targeted by cytoplasmic capping map to the vicinity of downstream CAGE tags.The cytoplasmic capping complex assembles on adapter protein nck1 bound to the proline-rich C-terminus of Mammalian capping enzyme A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay.Cap homeostasis is independent of poly(A) tail length.Stress and the nonsense-mediated RNA decay pathway.Nonsense-mediated mRNA decay at the crossroads of many cellular pathways RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs.

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SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA.

http://www.wikidata.org/entity/Q35005149

description

2013 nî lūn-bûn

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2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

SMG6 cleavage generates metast ...... ense-containing β-globin mRNA.

@ast

SMG6 cleavage generates metast ...... ense-containing β-globin mRNA.

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type

label

SMG6 cleavage generates metast ...... ense-containing β-globin mRNA.

@ast

SMG6 cleavage generates metast ...... ense-containing β-globin mRNA.

@en

prefLabel

SMG6 cleavage generates metast ...... ense-containing β-globin mRNA.

@ast

SMG6 cleavage generates metast ...... ense-containing β-globin mRNA.

@en

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JOURNAL.PONE.0074791

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SMG6 cleavage generates metast ...... ense-containing β-globin mRNA.

@en

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Julie A Dougherty

http://www.w3.org/2001/XMLSchema#string

Roshan Mascarenhas

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P2860

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

mRNA stability in mammalian cells

c-Src activates endonuclease-mediated mRNA decay.

Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice.

A rapid and sensitive method to detect siRNA-mediated mRNA cleavage in vivo using 5' RACE and a molecular beacon probe

Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5' termini.

Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases.

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e74791

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scholarly article

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10.1371/JOURNAL.PONE.0074791

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9

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8

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Daniel R Schoenberg

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2013-09-25T00:00:00Z

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257302261

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24086375

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3783490

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