SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay - Test2 - elhamkhani - TriplyDB

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

http://www.wikidata.org/entity/Q24302039

about

DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact Nonsense-mediated mRNA decay: inter-individual variability and human disease Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6 Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit.Organizing principles of mammalian nonsense-mediated mRNA decay Novel roles of the multi-functional CCR4-NOT complex in post-transcriptional regulation.Tudor Domain Containing Protein 3 Promotes Tumorigenesis and Invasive Capacity of Breast Cancer Cells A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.Transcriptome-wide modulation of splicing by the exon junction complex.Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells.SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA.Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question.Identification of elements in human long 3' UTRs that inhibit nonsense-mediated decay.N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD Mechanisms of endonuclease-mediated mRNA decay Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6 Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains.Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1.NMD: a multifaceted response to premature translational termination.Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders.Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.Mechanism of the initiation of mRNA decay: role of eRF3 family G proteins.Regulation of nonsense-mediated mRNA decay.Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human health.Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay.Mechanism, factors, and physiological role of nonsense-mediated mRNA decay.Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity.Recent structural studies on Dom34/aPelota and Hbs1/aEF1α: important factors for solving general problems of ribosomal stall in translation.The exon junction complex: a lifelong guardian of mRNA fate.p-4S-UPF1 recruits SMG5; SMG7; SMG6; PNRC2; DCP1A; and PP2A Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex Analysis of nonsense-mediated mRNA decay in mammalian cells.The RNA surveillance proteins UPF1, UPF2 and SMG6 affect HIV-1 reactivation at a post-transcriptional level.

P2860

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P2860

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

http://www.wikidata.org/entity/Q24302039

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

SMG6 interacts with the exon j ...... r nonsense-mediated mRNA decay

@ast

SMG6 interacts with the exon j ...... r nonsense-mediated mRNA decay

@en

SMG6 interacts with the exon j ...... r nonsense-mediated mRNA decay

@en-gb

SMG6 interacts with the exon j ...... r nonsense-mediated mRNA decay

@nl

type

label

SMG6 interacts with the exon j ...... r nonsense-mediated mRNA decay

@ast

SMG6 interacts with the exon j ...... r nonsense-mediated mRNA decay

@en

SMG6 interacts with the exon j ...... r nonsense-mediated mRNA decay

@en-gb

SMG6 interacts with the exon j ...... r nonsense-mediated mRNA decay

@nl

prefLabel

SMG6 interacts with the exon j ...... r nonsense-mediated mRNA decay

@ast

SMG6 interacts with the exon j ...... r nonsense-mediated mRNA decay

@en

SMG6 interacts with the exon j ...... r nonsense-mediated mRNA decay

@en-gb

SMG6 interacts with the exon j ...... r nonsense-mediated mRNA decay

@nl

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P2860

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Q24302039-D038C1B9-9F39-4402-9EB1-8E1BB6D52EDB

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Q24302039-307482D3-CC7D-4E3D-B6C6-42084D59BDEB

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P1433

Genes & Development

P1476

SMG6 interacts with the exon j ...... r nonsense-mediated mRNA decay

@en

P2093

Gretel Buchwald

http://www.w3.org/2001/XMLSchema#string

Isao Kashima

http://www.w3.org/2001/XMLSchema#string

Uma Jayachandran

http://www.w3.org/2001/XMLSchema#string

P2860

Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

Y14 and hUpf3b form an NMD-activating complex

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation

P304

2440-50

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1101/GAD.604610

http://www.w3.org/2001/XMLSchema#string

P407

P433

21

http://www.w3.org/2001/XMLSchema#string

P478

24

http://www.w3.org/2001/XMLSchema#string

P50

Elisa Izaurralde

P577

2010-11-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

47370147

http://www.w3.org/2001/XMLSchema#string

P698

20930030

http://www.w3.org/2001/XMLSchema#string

P921

R3H domain and coiled-coil containing 1 like

SMG6 nonsense mediated mRNA decay factor

Tudor domain containing 3

P932

2964754

http://www.w3.org/2001/XMLSchema#string