Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene

Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene

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http://www.wikidata.org/entity/Q35015352

Q35015352

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Detection of benzo[a]pyrene-guanine adducts in single-stranded DNA using the α-hemolysin nanopore Disturbance in testosterone production in leydig cells by polycyclic aromatic hydevrepocarbons Advances in chemical carcinogenesis: a historical review and prospective Chemical carcinogens: a review of the science and its associated principles. U.S. Interagency Staff Group on Carcinogens Modification of DNA by the benzo[a]pyrene metabolite diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene.Phenotyping cytochromes P450 with monoclonal antibodies.Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant.Excision repair of benzo[a]pyrene-deoxyguanosine adducts in baby hamster kidney 21/C13 cells and in secondary mouse embryo fibroblasts C57BL/6J A bacteriophage system for screening and study of biologically active polycyclic aromatic hydrocarbons and related compounds.Mechanism of biosynthesis of methylsulfones from PCBs and related compounds.Mutagenicity and cytotoxicity of benz[alpha]anthracene diol epoxides and tetrahydro-epoxides: exceptional activity of the bay region 1,2-epoxides Mechanism of phage phiX174 DNA inactivation by benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide.Polycyclic aromatic hydrocarbon-DNA adduct formation in prostate carcinogenesis.Phenotyping of cytochromes P-450 in human tissues with monoclonal antibodies Mechanism of the inhibition of mutagenicity of a benzo[a]pyrene 7,8-diol 9,10-epoxide by riboflavin 5'-phosphate Base insertion and deletion mutations induced in an Escherichia coli plasmid by benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide Fungal oxidation of (+/-)-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene: formation of diastereomeric benzo[a]pyrene 9,10-diol 7,8-epoxides.Specificity in interaction of benzo[a]pyrene with nuclear macromolecules: implication of derivatives of two dihydrodiols in protein binding Mutagenicity and tumorigenicity of the four enantiopure bay-region 3,4-diol-1,2-epoxide isomers of dibenz[a,h]anthracene Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase.Identification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cells.Regio- and stereoselectivity of various forms of purified cytochrome P-450 in the metabolism of benzo[a]pyrene and (-) trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as shown by product formation and binding to DNA.Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.Identification of four trans-3,4-dihydrodiol metabolites of 7,12-dimethylbenz[a]anthracene and their in vitro DNA-binding activities upon further metabolism.Benzo[a]pyrene induces the transcription of cyclooxygenase-2 in vascular smooth muscle cells. Evidence for the involvement of extracellular signal-regulated kinase and NF-kappaB.A critical overview on the biological and molecular features of red and processed meat in colorectal carcinogenesis.Procedures of determining organic trace compounds in municipal sewage sludge-a review.Novel drug metabolites produced by functionalization reactions: chemistry and toxicology.Repair of DNA damage induced by ionizing radiation and benzo[a]pyrene in mammalian cells.Aryl hydrocarbon hydroxylase and benzo[a] pyrene metabolism in rodent liver and human cels.Covalent binding of benzo[a]pyrene diol epoxide to DNA of mouse skin: in vivo persistence of adducts formation.Computer modelling studies of the covalent interactions between DNA and the enantiomers of anti-7,8-diol,9,10-epoxy-benzo[a]pyrene.Stereoselective metabolism of 8- and 9-fluorobenzo[a]pyrene by rat liver microsomes: absolute configurations of trans-dihydrodiol metabolites.Arachidonic acid-dependent metabolism of 7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene by ram seminal vesicles.Metabolism and cytotoxicity of benzo(a)pyrene in the human lung tumour cell line NCI-H322.Dissecting the mechanisms and molecules underlying the potential carcinogenicity of red and processed meat in colorectal cancer (CRC): an overview on the current state of knowledge.Studies on covalent binding of (-)trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene metabolites to cytochromes P-450 LM2 and LM4 and NADPH-cytochrome P-450 reductase.Toxic agents resulting from the oxidative metabolism of steroid hormones and drugs.

P2860

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P2860

Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene

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http://www.wikidata.org/entity/Q35015352

description

1976 nî lūn-bûn

@nan

1976 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

1976 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

1976年の論文

@ja

1976年論文

@yue

1976年論文

@zh-hant

1976年論文

@zh-hk

1976年論文

@zh-mo

1976年論文

@zh-tw

1976年论文

@wuu