Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes. - Test2 - elhamkhani - TriplyDB

Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes.

Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes.

http://www.wikidata.org/entity/Q35022080

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Slicing-independent RISC activation requires the argonaute PAZ domain Anatomy of RISC: how do small RNAs and chaperones activate Argonaute proteins?Slicer-independent mechanism drives small-RNA strand separation during human RISC assembly Organic small hairpin RNAs (OshR): a do-it-yourself platform for transgene-based gene silencing.MicroRNAs in inner ear biology and pathogenesis.The roles of individual mammalian argonautes in RNA interference in vivo.Improved siRNA/shRNA functionality by mismatched duplex.The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo.Elements and machinery of non-coding RNAs: toward their taxonomy.Molecular dissection of human Argonaute proteins by DNA shuffling.Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer.Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys.The multiple functions of TRBP, at the hub of cell responses to viruses, stress, and cancer.Off Target, but Sequence-Specific, shRNA-Associated Trans-Activation of Promoter Reporters in Transient Transfection Assays.Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing Embedding siRNA sequences targeting apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacy The anti-genomic (negative) strand of Hepatitis C Virus is not targetable by shRNA.Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants Guidelines for the optimal design of miRNA-based shRNAs.Studies of efficacy and liver toxicity related to adeno-associated virus-mediated RNA interference.Design of siRNA Therapeutics from the Molecular Scale Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines.Argonaute-3 activates the let-7a passenger strand microRNA.Effects of RNAi-mediated knockdown of Xist on the developmental efficiency of cloned male porcine embryos.Novel functional small RNAs are selectively loaded onto mammalian Ago1.Antiviral RNAi: translating science towards therapeutic success.miRNA-like duplexes as RNAi triggers with improved specificity Regulation of miRNA strand selection: follow the leader?Delivery and targeting of miRNAs for treating liver fibrosis.Modulation of the RNA Interference Activity Using Central Mismatched siRNAs and Acyclic Threoninol Nucleic Acids (aTNA) Units.Progress in micro RNA focused research in endocrinology.Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease.Thermal Stability of siRNA Modulates Aptamer- conjugated siRNA Inhibition.siPools: highly complex but accurately defined siRNA pools eliminate off-target effects.Does base-pairing strength play a role in microRNA repression?The Business of RNAi Therapeutics in 2012 Profiling the Mismatch Tolerance of Argonaute 2 through Deep Sequencing of Sliced Polymorphic Viral RNAs.Regulation of insulin resistance and type II diabetes by hepatitis C virus infection: A driver function of circulating miRNAs.XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer.Argonaute3 is a key player in miRNA-mediated target cleavage and translational repression in Chlamydomonas.

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Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes.

http://www.wikidata.org/entity/Q35022080

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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Thermodynamic stability of sma ...... ifferent mammalian Argonautes.

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Thermodynamic stability of sma ...... ifferent mammalian Argonautes.

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Thermodynamic stability of sma ...... ifferent mammalian Argonautes.

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Thermodynamic stability of sma ...... ifferent mammalian Argonautes.

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Proceedings of the National Academy of Sciences of the United States of America

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Thermodynamic stability of sma ...... ifferent mammalian Argonautes.

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P2093

Dirk Grimm

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Feijie Zhang

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John J Rossi

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Lan Jin

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Mark A Kay

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Shuo Gu

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Yong Huang

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P2860

Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

Identification of novel argonaute-associated proteins

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

ATP-dependent human RISC assembly pathways

Mfold web server for nucleic acid folding and hybridization prediction

Cleavage of the siRNA passenger strand during RISC assembly in human cells

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

Argonaute2 is the catalytic engine of mammalian RNAi

Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure

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51130794

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21576459

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3107324

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