Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: in vivo and in vitro findings in severe malarial anemia.

Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: in vivo and in vitro findings in severe malarial anemia.

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Q35073806

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Infection-related hemolysis and susceptibility to Gram-negative bacterial co-infection Mechanisms underlying the induction of regulatory T cells and its relevance in the adaptive immune response in parasitic infections A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia CD4 T-cell expression of IFN-γ and IL-17 in pediatric malarial anemia.Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation Host Resistance to Plasmodium-Induced Acute Immune Pathology Is Regulated by Interleukin-10 Receptor Signaling.Alterations in early cytokine-mediated immune responses to Plasmodium falciparum infection in Tanzanian children with mineral element deficiencies: a cross-sectional survey.Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria.Malaria, erythrocytic infection, and anemia.Severe malarial anemia: innate immunity and pathogenesis.The mucosal inflammatory response to non-typhoidal Salmonella in the intestine is blunted by IL-10 during concurrent malaria parasite infection Gene-gene interaction and functional impact of polymorphisms on innate immune genes in controlling Plasmodium falciparum blood infection level.Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults Hematological predictors of increased severe anemia in Kenyan children coinfected with Plasmodium falciparum and HIV-1.Increased interleukin-10 and interferon-γ levels in Plasmodium vivax malaria suggest a reciprocal regulation which is not altered by IL-10 gene promoter polymorphism.Identification of inflammatory biomarkers for pediatric malarial anemia severity using novel statistical methods.Interleukin-10 (IL-10) polymorphisms are associated with IL-10 production and clinical malaria in young children.Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case-control study Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia.Increased circulating interleukin (IL)-23 in children with malarial anemia: in vivo and in vitro relationship with co-regulatory cytokines IL-12 and IL-10.Oxidative stress in malaria.Adenosine A2A receptor and TNF-α regulate the circadian machinery of the human monocytic THP-1 cells.Cysticerci drive dendritic cells to promote in vitro and in vivo Tregs differentiation.Reduced Parasite Burden in Children with Falciparum Malaria and Bacteremia Coinfections: Role of Mediators of Inflammation Immune activation and regulation in simian immunodeficiency virus-Plasmodium fragile-coinfected rhesus macaques.Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production.Suppression of a novel hematopoietic mediator in children with severe malarial anemia.Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism.Malarial pigment hemozoin and the innate inflammatory response.Hemozoin inhibition and control of clinical malaria.Pro- and anti-inflammatory cytokines in children with malaria in Franceville, Gabon.Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity.Immunopathological effects of malaria pigment or hemozoin and other crystals.Do you see what I see: Recognition of protozoan parasites by Toll-like receptors.DC-Derived IL-10 Modulates Pro-inflammatory Cytokine Production and Promotes Induction of CD4+IL-10+ Regulatory T Cells during Plasmodium yoelii Infection.Human immune responses to Plasmodium falciparum infection: molecular evidence for a suboptimal THαβ and TH17 bias over ideal and effective traditional TH1 immune response.Mechanisms of erythropoiesis inhibition by malarial pigment and malaria-induced proinflammatory mediators in an in vitro model.IL12B polymorphisms are linked but not associated with Plasmodium falciparum parasitemia: a familial study in Burkina Faso.Evaluating anti-disease immunity to malaria and implications for vaccine design.DEAD-box proteins, like Leishmania eIF4A, modulate interleukin (IL)-12, IL-10 and tumour necrosis factor-alpha production by human monocytes.

P2860

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P2860

Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: in vivo and in vitro findings in severe malarial anemia.

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