Initiation of TCR signaling: regulation within CD3 dimers.
about
T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformationStructural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptorStructural and Functional Evidence that Nck Interaction with CD3ε Regulates T-Cell Receptor ActivityPhosphorylation site dynamics of early T-cell receptor signalingNon-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation.The SCHOOL of nature: I. Transmembrane signaling.Stoichiometry and intracellular fate of TRIM-containing TCR complexes.Mechanism of T cell tolerance induced by myeloid-derived suppressor cells.Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein.Organization of the resting TCR in nanoscale oligomers.Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.Normal T-cell development and immune functions in TRIM-deficient mice.A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection.Surface T-cell antigen receptor expression and availability for long-term antigenic signaling.TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response.Stoichiometry of the murine gammadelta T cell receptorCo-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity.A PCR-Based Method to Genotype Mice Knocked Out for All Four CD3 Subunits, the Standard Recipient Strain for Retrogenic TCR/CD3 Bone Marrow Reconstitution Technology.Signaling defects in anti-tumor T cellsCrystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.The Allostery Model of TCR Regulation.T cell immunoengineering with advanced biomaterials.Loss of N-terminal charged residues of mouse CD3 epsilon chains generates isoforms modulating antigen T cell receptor-mediated signals and T cell receptor-CD3 interactions.CD8+ cytotoxic T lymphocyte activation by soluble major histocompatibility complex-peptide dimers.Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes.Meeting report: Signal transduction meets systems biology.Detection of constant domain of human T cell antigen receptor alpha-chain via novel monoclonal antibody 7F18.Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell DevelopmentThe proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling.The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes.Fc receptor gamma chain residues at the interface of the cytoplasmic and transmembrane domains affect association with FcalphaRI, surface expression, and function.Selected signalling proteins recruited to the T-cell receptor-CD3 complex.Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation.Patients with CD3G mutations reveal a role for human CD3γ in Treg diversity and suppressive function.Rare autoimmune disorders with Mendelian inheritance.
P2860
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P2860
Initiation of TCR signaling: regulation within CD3 dimers.
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Initiation of TCR signaling: regulation within CD3 dimers.
@ast
Initiation of TCR signaling: regulation within CD3 dimers.
@en
type
label
Initiation of TCR signaling: regulation within CD3 dimers.
@ast
Initiation of TCR signaling: regulation within CD3 dimers.
@en
prefLabel
Initiation of TCR signaling: regulation within CD3 dimers.
@ast
Initiation of TCR signaling: regulation within CD3 dimers.
@en
P2860
P1476
Initiation of TCR signaling: regulation within CD3 dimers.
@en
P2093
Pilar Delgado
P2860
P356
10.1034/J.1600-065X.2003.00017.X
P577
2003-02-01T00:00:00Z