The combinatorial synthesis of bicyclic privileged structures or privileged substructures.
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Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitorsIsocyanide-Based Multicomponent Reactions for the Synthesis of HeterocyclesSolar synthesis: prospects in visible light photocatalysisThe azaindole framework in the design of kinase inhibitorsInhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamidesSalicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequenceA natural-product switch for a dynamic protein interfaceDesign and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 18-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction1,4-benzodiazepin-2-ones in medicinal chemistryDiversity-oriented synthesis: exploring the intersections between chemistry and biology.Fluorous mixture synthesis of two libraries with hydantoin-, and benzodiazepinedione-fused heterocyclic scaffolds.Microwave-Enhanced High-Speed Fluorous Synthesis.Fluorous synthesis of sclerotigenin-type benzodiazepine-quinazolinones.Fluorous Synthesis of Hydantoin-, Piperazinedione-, and Benzodiazepinedione-Fused Tricyclic and Tetracyclic Ring Systems.Chemical substructures that enrich for biological activityCombinatorial libraries of bis-heterocyclic compounds with skeletal diversity.Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressureApplications of multicomponent reactions to the synthesis of diverse heterocyclic scaffoldsSynthesis of a high-purity chemical library reveals a potent inducer of oxidative stress1,4-Thienodiazepine-2,5-diones via MCR (II): scaffold hopping by Gewald and Ugi-deprotection-cyclization strategyRuthenium-Catalyzed C-H Arylation of Benzoic Acids and Indole Carboxylic Acids with Aryl HalidesIntegration of small-molecule discovery in academic biomedical researchLigand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptorsPrivileged diazepine compounds and their emergence as bromodomain inhibitors.1,3-allylic strain as a strategic diversification element for constructing libraries of substituted 2-arylpiperidines.Mild decarboxylative allylation of coumarins.An integrated drug-likeness study for bicyclic privileged structures: from physicochemical properties to in vitro ADME properties.Synthesis of Diverse Heterocyclic Scaffolds via Tandem Additions to Imine Derivatives and Ring-Forming Reactions.Intermolecular C-O addition of carboxylic acids to arynes.Enantiomeric separation of biaryl atropisomers using cyclofructan based chiral stationary phases.Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides.Synthesis of novel 4H-pyrimido[1,6-a]pyrimidines via a one-pot three-component condensation.Synthesis of bis-indole carboxamides as G-quadruplex stabilizing and inducing ligands.Application of a sequential multicomponent assembly process/huisgen cycloaddition strategy to the preparation of libraries of 1,2,3-triazole-fused 1,4-benzodiazepines.Nitroso Diels-Alder (NDA) reaction as an efficient tool for the functionalization of diene-containing natural productsEvolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversificationAPPLICATIONS OF MULTICOMPONENT ASSEMBLY PROCESSES TO THE FACILE SYNTHESES OF DIVERSELY FUNCTIONALIZED NITROGEN HETEROCYCLES.CuAAC click chemistry accelerates the discovery of novel chemical scaffolds as promising protein tyrosine phosphatases inhibitors
P2860
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P2860
The combinatorial synthesis of bicyclic privileged structures or privileged substructures.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The combinatorial synthesis of ...... s or privileged substructures.
@ast
The combinatorial synthesis of ...... s or privileged substructures.
@en
type
label
The combinatorial synthesis of ...... s or privileged substructures.
@ast
The combinatorial synthesis of ...... s or privileged substructures.
@en
prefLabel
The combinatorial synthesis of ...... s or privileged substructures.
@ast
The combinatorial synthesis of ...... s or privileged substructures.
@en
P356
P1433
P1476
The combinatorial synthesis of bicyclic privileged structures or privileged substructures
@en
P2093
Douglas A Horton
P304
P356
10.1021/CR020033S
P577
2003-03-01T00:00:00Z