Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4 - Test2 - elhamkhani - TriplyDB

Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4

Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4

http://www.wikidata.org/entity/Q35096087

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Genomic/Epigenomic Alterations in Ovarian Carcinoma: Translational Insight into Clinical Practice Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer SWI/SNF chromatin remodeling complexes and cancer Distinct genetic alterations in small cell carcinoma from different anatomic sites SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers The disparate origins of ovarian cancers: pathogenesis and prevention strategies.A Comprehensive Review of Pediatric Tumors and Associated Cancer Predisposition Syndromes.Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma.High frequency of TERT promoter mutation in small cell carcinoma of bladder, but not in small cell carcinoma of other origins In vitro and in vivo therapeutic approach for a small cell carcinoma of the ovary hypercalcaemic type using a SCCOHT-1 cellular model.Beware of immunohistochemistry--report of a cytokeratin-, desmin- and INI-1-negative pelvic desmoplastic small round cell tumor in a 51 year old woman.Germline SMARCA4 mutations in patients with ovarian small cell carcinoma of hypercalcemic type.Primary rhabdoid tumor of the ovary: When large cells become small cells.Chromatin Remodelers: From Function to Dysfunction.Intra-Gene DNA Methylation Variability Is a Clinically Independent Prognostic Marker in Women's Cancers.Early-Stage Induction of SWI/SNF Mutations during Esophageal Squamous Cell Carcinogenesis.Germline Variants of Prostate Cancer in Japanese Families.Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma.Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type c-Met inhibitors attenuate tumor growth of small cell hypercalcemic ovarian carcinoma (SCCOHT) populations.Loss of SMARCA4 Expression Is Both Sensitive and Specific for the Diagnosis of Small Cell Carcinoma of Ovary, Hypercalcemic Type Loss of the tumor suppressor SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).Ovarian small-cell carcinoma hypercalcemic type successfully treated: a case report and literature review Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor.Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas.BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.Genomic alterations in neuroendocrine cancers of the ovary.No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour.Phenotype and genotype in Nicolaides-Baraitser syndrome.Vulnerabilities of mutant SWI/SNF complexes in cancer.A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.Cancer genomics: why rare is valuable.Categorization of cancer through genomic complexity could guide research and management strategies.Biology and Treatment of Rhabdoid Tumor.Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT): A review of 47 cases.SMARCA4 inactivating mutations cause concomitant Coffin-Siris syndrome, microphthalmia and small-cell carcinoma of the ovary hypercalcaemic type The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcaemic type.

P2860

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P2860

Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4

http://www.wikidata.org/entity/Q35096087

description

2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年论文

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Small cell carcinoma of the ov ...... d somatic mutations in SMARCA4

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Small cell carcinoma of the ov ...... d somatic mutations in SMARCA4

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Small cell carcinoma of the ov ...... d somatic mutations in SMARCA4

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Small cell carcinoma of the ov ...... d somatic mutations in SMARCA4

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Small cell carcinoma of the ov ...... d somatic mutations in SMARCA4

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Nature Genetics

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Small cell carcinoma of the ov ...... d somatic mutations in SMARCA4

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Aleksandar Sekulic

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Anthony N Karnezis

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Bodour Salhia

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David G Huntsman

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David W Craig

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Heather E Cunliffe

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Jaime Prat

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Jason J Corneveaux

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Jeffrey M Trent

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John H Farley

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P2860

Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation

Tissue microarrays for high-throughput molecular profiling of tumor specimens

The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner.

A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.

Spectrum of SMARCB1/INI1 mutations in familial and sporadic rhabdoid tumors.

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.

Small cell ovarian carcinoma: genomic stability and responsiveness to therapeutics.

Dose-dense and dose-intense chemotherapy for small cell ovarian cancer: 2 cases and review of literature.

Small cell carcinoma of the ovary of the hypercalcaemic type: an analysis of clinical and prognostic aspects of a rare disease on the basis of cases published in the literature.

Ovarian small cell carcinoma of hypercalcemic type - evidence of germline origin and SMARCA4 gene inactivation. a pilot study.

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427-429

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10.1038/NG.2928

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5

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46

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Joseph G Pressey

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Emanuela D'Angelo

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2014-03-23T00:00:00Z

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261033675

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