Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers. - Test2 - elhamkhani - TriplyDB

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.

http://www.wikidata.org/entity/Q35092542

about

Gene aberrations for precision medicine against lung adenocarcinoma Genetics and biology of pancreatic ductal adenocarcinoma Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas Targeting LKB1 in cancer - exposing and exploiting vulnerabilities Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5 Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases Synthetic lethality in lung cancer and translation to clinical therapies ScreenBEAM: a novel meta-analysis algorithm for functional genomics screens via Bayesian hierarchical modeling RNAi screening comes of age: improved techniques and complementary approaches SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers The disparate origins of ovarian cancers: pathogenesis and prevention strategies.Exome-Scale Discovery of Hotspot Mutation Regions in Human Cancer Using 3D Protein Structure.Systematic genomic and translational efficiency studies of uveal melanoma.Whole genome expression profiling shows that BRG1 transcriptionally regulates UV inducible genes and other novel targets in human cells Modulation of Brahma expression by the mitogen-activated protein kinase/extracellular signal regulated kinase pathway is associated with changes in melanoma proliferation.Collateral Lethality: A new therapeutic strategy in oncology Expression inactivation of SMARCA4 by microRNAs in lung tumors Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4 Prognostic gene signature identification using causal structure learning: applications in kidney cancer.Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation.High-throughput functional genomics using CRISPR-Cas9.Approaches to identifying synthetic lethal interactions in cancer.Genomic Characterization of Non-Small-Cell Lung Cancer in African Americans by Targeted Massively Parallel Sequencing The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma.Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs.Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62 Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer.Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma.Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma.The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies.Loss of the tumor suppressor SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor.Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies.

P2860

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P2860

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.

http://www.wikidata.org/entity/Q35092542

description

2014 nî lūn-bûn

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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի փետրվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Functional epigenetics approac ...... get in BRG1-deficient cancers.

@ast

Functional epigenetics approac ...... get in BRG1-deficient cancers.

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type

label

Functional epigenetics approac ...... get in BRG1-deficient cancers.

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Functional epigenetics approac ...... get in BRG1-deficient cancers.

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prefLabel

Functional epigenetics approac ...... get in BRG1-deficient cancers.

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Functional epigenetics approac ...... get in BRG1-deficient cancers.

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PNAS.1316793111

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Proceedings of the National Academy of Sciences of the United States of America

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Functional epigenetics approac ...... get in BRG1-deficient cancers.

@en

P2093

Alicia Lindeman

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Boris G Wilson

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Craig Mickanin

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Dongshu Chen

http://www.w3.org/2001/XMLSchema#string

Elizabeth Frias

http://www.w3.org/2001/XMLSchema#string

Frank Buxton

http://www.w3.org/2001/XMLSchema#string

Frank Stegmeier

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Gregory McAllister

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Gregory R Hoffman

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Huili Zhai

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P2860

The spectrum of SWI/SNF mutations, ubiquitous in human cancers

Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex

The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

ARID1A mutations in endometriosis-associated ovarian carcinomas

BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines

A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis

Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing

P304

3128-3133

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scholarly article

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10.1073/PNAS.1316793111

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8

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111

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Charles W Roberts

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2014-02-11T00:00:00Z

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24520176

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3939885

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