New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing. - Test2 - elhamkhani - TriplyDB

New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing.

New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing.

http://www.wikidata.org/entity/Q35100996

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The landscape of targeted therapies for cholangiocarcinoma: current status and emerging targets Genetic profiling of intrahepatic cholangiocarcinoma and its clinical implication in targeted therapy Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies Navigating the rapids: the development of regulated next-generation sequencing-based clinical trial assays and companion diagnostics SWI/SNF chromatin remodeling complexes and cancer Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation NTRK1 fusions for the therapeutic intervention of Korean patients with colon cancer.NTRK gene fusions as novel targets of cancer therapy across multiple tumour types The rise of the FGFR inhibitor in advanced biliary cancer: the next cover of time magazine?TRKing down an old oncogene in a new era of targeted therapy Targeted therapy in biliary tract cancers-current limitations and potentials in the future.Genomic profiling of intrahepatic cholangiocarcinoma: refining prognosis and identifying therapeutic targets.Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles.The potential role of comprehensive genomic profiling to guide targeted therapy for patients with biliary cancer.Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma Multiplexed gene expression profiling identifies the FGFR4 pathway as a novel biomarker in intrahepatic cholangiocarcinoma The landscape of kinase fusions in cancer CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.Dramatic response to dabrafenib and trametinib combination in a BRAF V600E-mutated cholangiocarcinoma: implementation of a molecular tumour board and next-generation sequencing for personalized medicine.Cholangiocarcinoma: molecular pathways and therapeutic opportunities Molecularly targeted therapies in non-small-cell lung cancer annual update 2014 Patterns of chromosomal copy-number alterations in intrahepatic cholangiocarcinoma Molecular diagnosis of intrahepatic cholangiocarcinoma.Molecular Targets in Biliary Carcinogenesis and Implications for Therapy.Liver cancer oncogenomics: opportunities and dilemmas for clinical applications.Establishment of a patient-derived intrahepatic cholangiocarcinoma xenograft model with KRAS mutation.A phase 1b study of Selumetinib in combination with Cisplatin and Gemcitabine in advanced or metastatic biliary tract cancer: the ABC-04 study.Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers.Molecular profiling of intrahepatic and extrahepatic cholangiocarcinoma using next generation sequencing NTRK1 rearrangement in colorectal cancer patients: evidence for actionable target using patient-derived tumor cell line.Forty-Year Trends in Cholangiocarcinoma Incidence in the U.S.: Intrahepatic Disease on the Rise.From Clinical Standards to Translating Next-Generation Sequencing Research into Patient Care Improvement for Hepatobiliary and Pancreatic Cancers Intratumoral heterogeneity of intrahepatic cholangiocarcinoma.Multimodal treatment strategies for advanced hilar cholangiocarcinoma.Molecular pathogenesis of intrahepatic cholangiocarcinoma.Detecting and targetting oncogenic fusion proteins in the genomic era.Role of the fibroblast growth factor receptor axis in cholangiocarcinoma.New Horizons for Precision Medicine in Biliary Tract Cancers.Emerging molecular targets and therapy for cholangiocarcinoma.

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P2860

New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing.

http://www.wikidata.org/entity/Q35100996

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2014 nî lūn-bûn

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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2014 թվականի փետրվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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New routes to targeted therapy ...... by next-generation sequencing.

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New routes to targeted therapy ...... by next-generation sequencing.

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New routes to targeted therapy ...... by next-generation sequencing.

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New routes to targeted therapy ...... by next-generation sequencing.

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New routes to targeted therapy ...... by next-generation sequencing.

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THEONCOLOGIST.2013-0352

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New routes to targeted therapy ...... by next-generation sequencing.

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Chaitanya Churi

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Christine E Sheehan

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Daniel V T Catenacci

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David M Jones

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Deborah Morosini

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Doron Lipson

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Gary Palmer

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Hwa J Lee

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Janne V Rand

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P2860

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

Modern diagnostic approaches to cholangiocarcinoma

Genetic profiling of intrahepatic cholangiocarcinoma

CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

Identification of targetable FGFR gene fusions in diverse cancers.

Fibroblast growth factors, their receptors and signaling

PTEN: life as a tumor suppressor

Fibroblast growth factor signalling: from development to cancer

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235-242

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10.1634/THEONCOLOGIST.2013-0352

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3

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cholangiocarcinoma

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