T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway.
about
Roles of microRNAs and long-noncoding RNAs in human immunodeficiency virus replicationTranscriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cureCracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFbPhosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytesNegative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat.Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation.Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications.Epigenetic heterogeneity in HIV-1 latency establishment.Viral-host interactions that control HIV-1 transcriptional elongationVisualization of positive transcription elongation factor b (P-TEFb) activation in living cells.Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2.Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression.Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation.Euphorbia Kansui Reactivates Latent HIV.PKC phosphorylates HEXIM1 and regulates P-TEFb activity.A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency.The Bin3 RNA methyltransferase targets 7SK RNA to control transcription and translationBarriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirsMagnesium decreases inflammatory cytokine production: a novel innate immunomodulatory mechanism.Novel neuroprotective GSK-3β inhibitor restricts Tat-mediated HIV-1 replication.Role of noncoding RNAs in the regulation of P-TEFb availability and enzymatic activityControl of HIV latency by epigenetic and non-epigenetic mechanisms.An integrated overview of HIV-1 latency.Progress and challenges in the use of latent HIV-1 reactivating agentsPromising Role of Toll-Like Receptor 8 Agonist in Concert with Prostratin for Activation of Silent HIV.Current views on HIV-1 latency, persistence, and cure.Cyclin-dependent kinases as therapeutic targets for HIV-1 infection.The viral protein Tat can inhibit the establishment of HIV-1 latency.The HIV-1 Tat protein: mechanism of action and target for HIV-1 cure strategies.Latent HIV-1 can be reactivated by cellular superinfection in a Tat-dependent manner, which can lead to the emergence of multidrug-resistant recombinant viruses.Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation.Incorporating the type and direction information in predicting novel regulatory interactions between HIV-1 and human proteins using a biclustering approach.SMADs and YAP compete to control elongation of β-catenin:LEF-1-recruited RNAPII during hESC differentiation.Systems analysis of latent HIV reversal reveals altered stress kinase signaling and increased cell death in infected T cells.HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.Proteomic Profiling of a Primary CD4+ T Cell Model of HIV-1 Latency Identifies Proteins Whose Differential Expression Correlates with Reactivation of Latent HIV-1.Hexim1, an RNA-controlled protein hub.Long Noncoding RNA uc002yug.2 Activates HIV-1 Latency through Regulation of mRNA Levels of Various RUNX1 Isoforms and Increased Tat Expression.Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation.
P2860
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P2860
T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
T-cell receptor signaling enha ...... ough an ERK-dependent pathway.
@ast
T-cell receptor signaling enha ...... ough an ERK-dependent pathway.
@en
type
label
T-cell receptor signaling enha ...... ough an ERK-dependent pathway.
@ast
T-cell receptor signaling enha ...... ough an ERK-dependent pathway.
@en
prefLabel
T-cell receptor signaling enha ...... ough an ERK-dependent pathway.
@ast
T-cell receptor signaling enha ...... ough an ERK-dependent pathway.
@en
P2093
P2860
P1476
T-cell receptor signaling enha ...... ough an ERK-dependent pathway.
@en
P2093
Jonathan Karn
Joseph Hokello
Uri Mbonye
Young Kyeung Kim
P2860
P304
P356
10.1016/J.JMB.2011.03.054
P407
P577
2011-07-01T00:00:00Z