Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA
about
The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SKInhibition of Tat activity by the HEXIM1 proteinCompensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcriptionHEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SKIdentification of HEXIM1 as a positive regulator of p53HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor bAcetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcriptionThe La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genesSystematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzymeThe structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylationThe integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokinesA human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFbBinding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitorThe Drosophila 7SK snRNP and the essential role of dHEXIM in developmentRegulatory long non-coding RNAs and neuronal disordersSteroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiationCrystal structure of HIV-1 Tat complexed with human P-TEFbLARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associatedRegulation of P-TEFb elongation complex activity by CDK9 acetylationDevelopmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcriptionA new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongationOligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFbP-TEFb goes viralRoles of microRNAs and long-noncoding RNAs in human immunodeficiency virus replicationRNA-Mediated Regulation of HMGA1 FunctionTranscriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cureCyclin Box Structure of the P-TEFb Subunit Cyclin T1 Derived from a Fusion Complex with EIAV TatStructure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFbStructural insights into the cyclin T1-Tat-TAR RNA transcription activation complex from EIAVAFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoterYeast Asc1p and mammalian RACK1 are functionally orthologous core 40S ribosomal proteins that repress gene expression.The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous ProteinsIdentification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 TatThe breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimerCracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFbSmall molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytesSR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase
P2860
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P2860
Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Inhibition of P-TEFb (CDK9/Cyc ...... ctions of HEXIM1 and 7SK snRNA
@ast
Inhibition of P-TEFb (CDK9/Cyc ...... ctions of HEXIM1 and 7SK snRNA
@en
Inhibition of P-TEFb (CDK9/Cyc ...... ctions of HEXIM1 and 7SK snRNA
@en-gb
Inhibition of P-TEFb (CDK9/Cyc ...... ctions of HEXIM1 and 7SK snRNA
@nl
type
label
Inhibition of P-TEFb (CDK9/Cyc ...... ctions of HEXIM1 and 7SK snRNA
@ast
Inhibition of P-TEFb (CDK9/Cyc ...... ctions of HEXIM1 and 7SK snRNA
@en
Inhibition of P-TEFb (CDK9/Cyc ...... ctions of HEXIM1 and 7SK snRNA
@en-gb
Inhibition of P-TEFb (CDK9/Cyc ...... ctions of HEXIM1 and 7SK snRNA
@nl
prefLabel
Inhibition of P-TEFb (CDK9/Cyc ...... ctions of HEXIM1 and 7SK snRNA
@ast
Inhibition of P-TEFb (CDK9/Cyc ...... ctions of HEXIM1 and 7SK snRNA
@en
Inhibition of P-TEFb (CDK9/Cyc ...... ctions of HEXIM1 and 7SK snRNA
@en-gb
Inhibition of P-TEFb (CDK9/Cyc ...... ctions of HEXIM1 and 7SK snRNA
@nl
P2093
P3181
P1433
P1476
Inhibition of P-TEFb (CDK9/Cyc ...... ctions of HEXIM1 and 7SK snRNA
@en
P2093
Andrew J Link
Jennifer L Jennings
Qiang Zhou
Rieko Nishimura
Ruichuan Chen
P304
P3181
P356
10.1016/S1097-2765(03)00388-5
P407
P577
2003-10-01T00:00:00Z