Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.
about
Regulatory network inferred using expression data of small sample size: application and validation in erythroid systemFetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathiesEpigenetic regulation of fetal globin gene expression in adult erythroid cellsBiased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cellsPGC-1 coactivator activity is required for murine erythropoiesis.Minireview: Pathophysiological roles of the TR4 nuclear receptor: lessons learned from mice lacking TR4Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation.The nuclear receptor gene family in the Pacific oyster, Crassostrea gigas, contains a novel subfamily groupGenomic and proteomic analysis of transcription factor TFII-I reveals insight into the response to cellular stress.An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference.Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin inductionCompound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genesRecent advances in the study of testicular nuclear receptor 4Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometryForced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypesThe LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell miceVariant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.The switch from fetal to adult hemoglobinPomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitorsASXL1 plays an important role in erythropoiesis.The genetic regulatory signature of type 2 diabetes in human skeletal muscle.Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell diseaseOriginal Research: Stable expression of miR-34a mediates fetal hemoglobin induction in K562 cells.The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition.Transcriptional environment and chromatin architecture interplay dictates globin expression patterns of heterospecific hybrids derived from undifferentiated human embryonic stem cells or from their erythroid progeny.TRIM28 is essential for erythroblast differentiation in the mouse.The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions.Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin.Alternative lengthening of telomeres: remodeling the telomere architecture.Recent trends for novel options in experimental biological therapy of β-thalassemia.Recent trends in the gene therapy of β-thalassemia.Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms.NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis).Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiationThe TRIMming on an erythroid repressor complex.Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.Fetal haemoglobin induction in sickle cell disease.Pharmacological and molecular approaches for the treatment of β-hemoglobin disorders.
P2860
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P2860
Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Nuclear receptors TR2 and TR4 ...... ntiated adult erythroid cells.
@ast
Nuclear receptors TR2 and TR4 ...... ntiated adult erythroid cells.
@en
type
label
Nuclear receptors TR2 and TR4 ...... ntiated adult erythroid cells.
@ast
Nuclear receptors TR2 and TR4 ...... ntiated adult erythroid cells.
@en
prefLabel
Nuclear receptors TR2 and TR4 ...... ntiated adult erythroid cells.
@ast
Nuclear receptors TR2 and TR4 ...... ntiated adult erythroid cells.
@en
P2093
P2860
P356
P1476
Nuclear receptors TR2 and TR4 ...... ntiated adult erythroid cells.
@en
P2093
Alexandra Amaral-Psarris
Frank Grosveld
James Douglas Engel
John Strouboulis
Katarzyna E Kolodziej
Lihong Shi
Naoshi Obara
Osamu Tanabe
Shuaiying Cui
P2860
P304
P356
10.1128/MCB.05310-11
P407
P577
2011-06-13T00:00:00Z