Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers.
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Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agentsNeurotrophic Factors and Their Potential Applications in Tissue Regeneration.Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can FlyMetformin and the gastrointestinal tractVariants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase.Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).The effect of dipyridamole on the pharmacokinetics of metformin: a randomized crossover study in healthy volunteers.The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.A Comprehensive Review of Drug-Drug Interactions with Metformin.Role of organic cation transporters in drug-drug interaction.A Structural Basis for Biguanide Activity.Effect of Liver Disease on Hepatic Transporter Expression and Function.Cation-selective transporters are critical to the AMPK-mediated antiproliferative effects of metformin in human breast cancer cells.Prediction and validation of enzyme and transporter off-targets for metformin.The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.Metformin-associated lactic acidosis (MALA): Moving towards a new paradigm.The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities.Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state.Analysis of drug-endogenous human metabolite similarities in terms of their maximum common substructures.Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidEffect of Serotonin Transporter 5-HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A GoDARTS Study.Functional identification of organic cation transporter 1 as an atenolol transporter sensitive to flavonoids.Pharmacokinetics of metformin in patients with gastrointestinal intolerance.Absorption sites of orally administered drugs in the small intestine.Differential Response of Human Hepatocyte Chromatin to HDAC Inhibitors as a Function of Microenvironmental Glucose Level.Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy.Metformin from mother to unborn child - Are there unwarranted effects?
P2860
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P2860
Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers.
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Four cation-selective transpor ...... min in Caco-2 cell monolayers.
@ast
Four cation-selective transpor ...... min in Caco-2 cell monolayers.
@en
type
label
Four cation-selective transpor ...... min in Caco-2 cell monolayers.
@ast
Four cation-selective transpor ...... min in Caco-2 cell monolayers.
@en
prefLabel
Four cation-selective transpor ...... min in Caco-2 cell monolayers.
@ast
Four cation-selective transpor ...... min in Caco-2 cell monolayers.
@en
P2093
P2860
P356
P1476
Four cation-selective transpor ...... min in Caco-2 cell monolayers.
@en
P2093
Chester L Costales
Dhiren R Thakker
Ruth S Everett
Tianxiang Kevin Han
William R Proctor
P2860
P304
P356
10.1124/JPET.114.220350
P407
P577
2015-01-06T00:00:00Z