Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling - Test2 - elhamkhani - TriplyDB

Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling

Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling

http://www.wikidata.org/entity/Q33799288

about

SLC transporters as therapeutic targets: emerging opportunities Protein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220 Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin.MATE1 regulates cellular uptake and sensitivity to imatinib in CML patients Molecular modeling and ligand docking for solute carrier (SLC) transporters Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds.Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers.Colloidal aggregation and the in vitro activity of traditional Chinese medicines The physiological role of drug transporters.Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.Combinatorial Pharmacophore Modeling of Multidrug and Toxin Extrusion Transporter 1 Inhibitors: a Theoretical Perspective for Understanding Multiple Inhibitory Mechanisms Making Transporter Models for Drug-Drug Interaction Prediction Mobile.Pharmacophore-based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB).The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.Role of ABC and Solute Carrier Transporters in the Placental Transport of Lamivudine.SLC Transporters: Structure, Function, and Drug Discovery.Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs).A Two-Period Open-Label, Single-Dose Crossover Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Between Cimetidine and Inhaled Extrafine CHF 5993.Emerging transporters of clinical importance: an update from the International Transporter Consortium.pH-dependent drug-drug interactions for weak base drugs: potential implications for new drug development.Nature and uses of fluorescent dyes for drug transporter studies.In silico ADME/T modelling for rational drug design.Computational modeling to predict the functions and impact of drug transporters.The Complexities of Interpreting Reversible Elevated Serum Creatinine Levels in Drug Development: Does a Correlation with Inhibition of Renal Transporters Exist?Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine.Prediction and validation of enzyme and transporter off-targets for metformin.The Role of Transporters in the Toxicity of Chemotherapeutic Drugs: Focus on Transporters for Organic Cations.Evaluation of the effect of cobicistat on the in vitro renal transport and cytotoxicity potential of tenofovir.Renal Drug Transporters and Drug Interactions.Lack of Influence of Substrate on Ligand Interaction with the Human Multidrug and Toxin Extruder, MATE1.Emtricitabine is a substrate of MATE1 but not of OCT1, OCT2, P-gp, BCRP or MRP2 transporters.Impact of Substrate-Dependent Inhibition on Renal Organic Cation Transporters hOCT2 and hMATE1/2-K-Mediated Drug Transport and Intracellular Accumulation.Indinavir Alters the Pharmacokinetics of Lamivudine Partially via Inhibition of Multidrug and Toxin Extrusion Protein 1 (MATE1).Renal vectorial transport of berberine mediated by organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins 1 (MATE1) in rats.Expression of MATE1, P-gp, OCTN1 and OCTN2, in epithelial and immune cells in the lung of COPD and healthy individuals.Nephrotoxicity Evaluation on Cisplatin Combined with 5-HT3 Receptor Antagonists: A Retrospective Study.

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Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling

http://www.wikidata.org/entity/Q33799288

description

2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013年の論文

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Discovery of potent, selective ...... ing and computational modeling

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Discovery of potent, selective ...... ing and computational modeling

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Discovery of potent, selective ...... ing and computational modeling

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Discovery of potent, selective ...... ing and computational modeling

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Alan Kosaka

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Arik A Zur

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Kari M Morrissey

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Kathleen M Giacomini

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Matthias B Wittwer

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Natalia Khuri

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Xuexiang Zhang

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Yasuto Kido

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Yong Huang

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P2860

DrugBank: a comprehensive resource for in silico drug discovery and exploration

A human transporter protein that mediates the final excretion step for toxic organic cations

DrugBank 3.0: a comprehensive resource for 'omics' research on drugs

Structure of a cation-bound multidrug and toxic compound extrusion transporter

DrugBank: a knowledgebase for drugs, drug actions and drug targets

Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects

Maraviroc: pharmacokinetics and drug interactions

Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters

Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs)

Membrane transporters in drug development

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