A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism.
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Immunoglobulin Fc Heterodimer Platform Technology: From Design to Applications in Therapeutic Antibodies and ProteinsFc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds.Fab-based bispecific antibody formats with robust biophysical properties and biological activityBispecific Antibodies Targeting Different Epitopes on the HIV-1 Envelope Exhibit Broad and Potent Neutralization.Computationally Designed Bispecific Antibodies using Negative State Repertoires.Effect of CD16a, the surface receptor of Kupffer cells, on the growth of hepatocellular carcinoma cells.A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair.Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells.The use of CrossMAb technology for the generation of bi- and multispecific antibodies.An efficient route to bispecific antibody production using single-reactor mammalian co-culture.Novel multispecific heterodimeric antibody format allowing modular assembly of variable domain fragments.Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry.Precise quantification of mixtures of bispecific IgG produced in single host cells by liquid chromatography-Orbitrap high-resolution mass spectrometry.The making of bispecific antibodiesComputational design of a specific heavy chain/κ light chain interface for expressing fully IgG bispecific antibodies.A native-like bispecific antibody suppresses the inflammatory cytokine response by simultaneously neutralizing tumor necrosis factor-alpha and interleukin-17A.Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies.Tethered-variable CL bispecific IgG: an antibody platform for rapid bispecific antibody screening.Novel CH1:CL interfaces that enhance correct light chain pairing in heterodimeric bispecific antibodies.Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies.Guiding bispecific monovalent antibody formation through proteolysis of IgG1 single-chain.An antibody with Fab-constant domains exchanged for a pair of CH3 domains.Expanding the Boundaries of Biotherapeutics with Bispecific Antibodies
P2860
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P2860
A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism.
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
A novel antibody engineering s ...... ctrostatic steering mechanism.
@ast
A novel antibody engineering s ...... ctrostatic steering mechanism.
@en
type
label
A novel antibody engineering s ...... ctrostatic steering mechanism.
@ast
A novel antibody engineering s ...... ctrostatic steering mechanism.
@en
prefLabel
A novel antibody engineering s ...... ctrostatic steering mechanism.
@ast
A novel antibody engineering s ...... ctrostatic steering mechanism.
@en
P2093
P2860
P356
P1476
A novel antibody engineering s ...... ectrostatic steering mechanism
@en
P2093
Esther C Leng
Ian N Foltz
Janelle Stoops
Kannan Gunasekaran
Kathy Manchulenko
Martin Pentony
Monique Howard
P2860
P304
P356
10.1074/JBC.M114.620260
P407
P577
2015-01-12T00:00:00Z