A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair. - Test2 - elhamkhani - TriplyDB

A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair.

A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair.

http://www.wikidata.org/entity/Q36973896

about

The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis MicroRNA-433-3p promotes osteoblast differentiation through targeting DKK1 expression Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms.Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma Bispecific Antibodies as a Development Platform for New Concepts and Treatment Strategies.Investigational anabolic agents for the treatment of osteoporosis: an update on recent developments.The Lrp4R1170Q Homozygous Knock-In Mouse Recapitulates the Bone Phenotype of Sclerosteosis in Humans.Role and mechanism of action of sclerostin in bone.The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis.Fracture healing physiology and the quest for therapies for delayed healing and nonunion.One Year of Abaloparatide, a Selective Activator of the PTH1 Receptor, Increased Bone Formation and Bone Mass in Osteopenic Ovariectomized Rats Without Increasing Bone Resorption.Osteoporosis treatment: recent developments and ongoing challenges.Molecular genetics and targeted therapy of WNT-related human diseases (Review).Sclerostin induced tumor growth, bone metastasis and osteolysis in breast cancer.Reduced β-catenin expression affects patterning of bone primordia, but not bone maturation.The making of bispecific antibodies Heterozygous deletion of both sclerostin (Sost) and connexin43 (Gja1) genes in mice is not sufficient to impair cortical bone modeling.A WNT protein therapeutic improves the bone-forming capacity of autografts from aged animals.Cushioning the cartilage: a canonical Wnt restricting matter.Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications.Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease.Bone-Targeted Therapies in Cancer-Induced Bone Disease.A systematic review of current osteoporotic metaphyseal fracture animal models.Bispecific antibodies: design, therapy, perspectives.Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation.Sclerostin expression and functions beyond the osteocyte.Bone diseases: Dual sclerostin-DKK1 antibody outperforms monotherapy.Association of Circulating Wnt Antagonists With Severe Abdominal Aortic Calcification in Elderly Women.Sclerostin Blockade-A Dual Mode of Action After All?Anabolic Strategies to Augment Bone Fracture Healing.Role of Osteocytes in Myeloma Bone Disease: Anti-sclerostin Antibody as New Therapeutic Strategy Rethinking Bone Disease in Kidney Disease

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A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair.

http://www.wikidata.org/entity/Q36973896

description

2016 nî lūn-bûn

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2016年の論文

@ja

2016年論文

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2016年論文

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2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

@wuu

2016年论文

@zh

2016年论文

@zh-cn

name

A bispecific antibody targetin ...... s accrual and fracture repair.

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type

label

A bispecific antibody targetin ...... s accrual and fracture repair.

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prefLabel

A bispecific antibody targetin ...... s accrual and fracture repair.

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Nature Communications

P1476

A bispecific antibody targetin ...... s accrual and fracture repair.

@en

P2093

Amy N Duguay

http://www.w3.org/2001/XMLSchema#string

Banghua Sun

http://www.w3.org/2001/XMLSchema#string

Barbara Tipton

http://www.w3.org/2001/XMLSchema#string

Brenda Heron

http://www.w3.org/2001/XMLSchema#string

Brian D Soriano

http://www.w3.org/2001/XMLSchema#string

Chaoyang Li

http://www.w3.org/2001/XMLSchema#string

Chun-Ya Han

http://www.w3.org/2001/XMLSchema#string

Efrain Pacheco

http://www.w3.org/2001/XMLSchema#string

Emil Brisan

http://www.w3.org/2001/XMLSchema#string

Franklin J Asuncion

http://www.w3.org/2001/XMLSchema#string

P2860

FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6

The interpretation of protein structures: estimation of static accessibility

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

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11505

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scholarly article

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10.1038/NCOMMS11505

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7

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2016-05-27T00:00:00Z

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27230681

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4894982

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