Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
about
Different human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in miceHuman Stem Cell-Derived Astrocytes: Specification and Relevance for Neurological DisordersAdeno Associated Viral Vector Delivered RNAi for Gene Therapy of SOD1 Amyotrophic Lateral SclerosisQuo vadis motor neuron disease?Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane VesiclesNeuroinflammation in motor neuron diseaseElusive roles for reactive astrocytes in neurodegenerative diseasesAstrocytes conspire with neurons during progression of neurological diseaseConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisGlia: an emerging target for neurological disease therapyInduced pluripotent stem cells from ALS patients for disease modelingMicroglia centered pathogenesis in ALS: insights in cell interconnectivityTherapeutic neuroprotective agents for amyotrophic lateral sclerosisBlood-CNS Barrier Impairment in ALS patients versus an animal modelStem cells in the nervous systemA large animal model of spinal muscular atrophy and correction of phenotype.Structural switching of Cu,Zn-superoxide dismutases at loop VI: insights from the crystal structure of 2-mercaptoethanol-modified enzymeTherapeutic applications of mesenchymal stem cells for amyotrophic lateral sclerosis.Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and researchAstrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALSA perspective on stem cell modeling of amyotrophic lateral sclerosisEmerging mechanisms of molecular pathology in ALSRNA-targeted Therapeutics for ALSPrion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosisA novel acylaminoimidazole derivative, WN1316, alleviates disease progression via suppression of glial inflammation in ALS mouse modelHuman stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypesMajor histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutantsAstrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm.Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis.Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model.Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo.Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration.Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model.Human glial progenitor engraftment and gene expression is independent of the ALS environmentMotor neuron vulnerability and resistance in amyotrophic lateral sclerosis.
P2860
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P2860
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
@ast
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
@en
type
label
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
@ast
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
@en
prefLabel
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
@ast
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
@en
P2093
P2860
P356
P1433
P1476
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
@en
P2093
Amanda M Haidet-Phillips
Anja Kammesheidt
Ashley Christensen
Ashley Frakes
Brian K Kaspar
Carlos J Miranda
Jerry R Mendell
Kathrin Meyer
Kevin D Foust
P2860
P2888
P304
P356
10.1038/NBT.1957
P50
P577
2011-08-10T00:00:00Z