High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling. - Test2 - elhamkhani - TriplyDB

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.

http://www.wikidata.org/entity/Q35208383

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Notch signaling: its roles and therapeutic potential in hematological malignancies Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?Crosstalk of the Insulin-Like Growth Factor Receptor with the Wnt Signaling Pathway in Breast Cancer Long non-coding RNAs in normal and malignant hematopoiesis The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem Cells Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia.A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies.Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression A parallel-arm phase I trial of the humanised anti-IGF-1R antibody dalotuzumab in combination with the AKT inhibitor MK-2206, the mTOR inhibitor ridaforolimus, or the NOTCH inhibitor MK-0752, in patients with advanced solid tumours.Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.Insulin growth factor 1 receptor expression is associated with NOTCH1 mutation, trisomy 12 and aggressive clinical course in chronic lymphocytic leukaemia.Inhibition of type I insulin-like growth factor receptor tyrosine kinase by picropodophyllin induces apoptosis and cell cycle arrest in T lymphoblastic leukemia/lymphoma.Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK⁺ T-cell lymphoma The role of Notch receptors in transcriptional regulation Inhibition of IGF1-R overcomes IGFBP7-induced chemotherapy resistance in T-ALL.Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor.IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias.HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.Defined, serum-free conditions for in vitro culture of primary human T-ALL blasts.Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation.Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.The NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy.The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors.MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.The emerging role of insulin and insulin-like growth factor signaling in cancer stem cells.c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights PPAR-γ Agonists As Antineoplastic Agents in Cancers with Dysregulated IGF Axis.Type I insulin-like growth factor receptor signaling in hematological malignancies.Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity.Outlook on PI3K/AKT/mTOR inhibition in acute leukemia.Targeting the mTOR Pathway in Leukemia.

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High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.

http://www.wikidata.org/entity/Q35208383

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

High-level IGF1R expression is ...... supported by Notch signaling.

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High-level IGF1R expression is ...... supported by Notch signaling.

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High-level IGF1R expression is ...... supported by Notch signaling.

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Journal of Experimental Medicine

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Andrew P Weng

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Carol Wai

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Hongfang Wang

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Jen-Chieh Tseng

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Joan Carboni

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Jon C Aster

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Marco Gottardis

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Michael Pollak

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Oksana Nemirovsky

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Samuel Gusscott

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P2860

Efficient tumour formation by single human melanoma cells

Genomic targets of the human c-Myc protein

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription

Signalling downstream of activated mammalian Notch

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

FOXO transcription factors at the interface between longevity and tumor suppression

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1809-1822

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scholarly article

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10.1084/JEM.20110121

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9

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208

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Francoise Pflumio

Martin Holzenberger

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2011-08-01T00:00:00Z

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51539073

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21807868

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3171095

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