Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2) - Test2 - elhamkhani - TriplyDB

Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2)

Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2)

http://www.wikidata.org/entity/Q35210565

about

Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA Tissue-specific reduction in splicing efficiency of IKBKAP due to the major mutation associated with familial dysautonomia.Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo A positive modifier of spinal muscular atrophy in the SMN2 gene The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP The RNA Splicing Response to DNA Damage Spinal muscular atrophy: from gene discovery to clinical trials Applicability of histone deacetylase inhibition for the treatment of spinal muscular atrophy Splicing therapy for neuromuscular disease High expression level of Tra2-β1 is responsible for increased SMN2 exon 7 inclusion in the testis of SMA mice Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-β1 Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation An in vivo reporter system for measuring increased inclusion of exon 7 in SMN2 mRNA: potential therapy of SMA A short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophy SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c.SRp55 complex that either recruits or antagonizes htra2beta1 Splicing factor transformer-2β (Tra2β) regulates the expression of regulator of G protein signaling 4 (RGS4) gene and is induced by morphine Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development SMN in spinal muscular atrophy and snRNP biogenesis Site identification in high-throughput RNA-protein interaction data Pathological impact of SMN2 mis-splicing in adult SMA mice Subtle mutations in the SMN1 gene in Chinese patients with SMA: p.Arg288Met mutation causing SMN1 transcript exclusion of exon7.Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon.Prediction of alternatively skipped exons and splicing enhancers from exon junction arrays.Mouse survival motor neuron alleles that mimic SMN2 splicing and are inducible rescue embryonic lethality early in development but not late Spinal muscular atrophy: mechanisms and therapeutic strategies.Treatment of spinal muscular atrophy by sodium butyrate.Intron 7 conserved sequence elements regulate the splicing of the SMN genes.Splicing of the Survival Motor Neuron genes and implications for treatment of SMA Identification of novel compounds that increase SMN protein levels using an improved SMN2 reporter cell assay.A negatively acting bifunctional RNA increases survival motor neuron both in vitro and in vivo.TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy.Restoration of the cystic fibrosis transmembrane conductance regulator function by splicing modulation.A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype.SMN-inducing compounds for the treatment of spinal muscular atrophy.

P2860

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P2860

Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2)

http://www.wikidata.org/entity/Q35210565

description

2000 nî lūn-bûn

@nan

2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Htra2-beta 1 stimulates an exo ...... survival motor neuron 2 (SMN2)

@ast

Htra2-beta 1 stimulates an exo ...... survival motor neuron 2 (SMN2)

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type

label

Htra2-beta 1 stimulates an exo ...... survival motor neuron 2 (SMN2)

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Htra2-beta 1 stimulates an exo ...... survival motor neuron 2 (SMN2)

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prefLabel

Htra2-beta 1 stimulates an exo ...... survival motor neuron 2 (SMN2)

@ast

Htra2-beta 1 stimulates an exo ...... survival motor neuron 2 (SMN2)

@en

P1433

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P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Htra2-beta 1 stimulates an exo ...... survival motor neuron 2 (SMN2)

@en

P2093

B Wirth

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C L Lorson

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E J Androphy

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S Stamm

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Y Hofmann

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P2860

Cloning and domain structure of the mammalian splicing factor U2AF

Identification and characterization of three members of the human SR family of pre-mRNA splicing factors

Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing

Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly

SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements

A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions

The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)

Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis

Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform

P304

9618-9623

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scholarly article

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10.1073/PNAS.160181697

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17

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97

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242906988

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10931943

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P932

16914

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