Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence.
about
Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and PersistenceVpu Protein: The Viroporin Encoded by HIV-1Expression of HIV-1 Vpu leads to loss of the viral restriction factor CD317/Tetherin from lipid rafts and its enhanced lysosomal degradationAtomistic detailed mechanism and weak cation-conducting activity of HIV-1 Vpu revealed by free energy calculationsA consensus surface activation marker signature is partially dependent on human immunodeficiency virus type 1 Nef expression within productively infected macrophagesCell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 NefIntracellular overexpression of HIV-1 Nef impairs differentiation and maturation of monocytic precursors towards dendritic cellsCargo recognition in clathrin-mediated endocytosisBrain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteinsUnderstanding the MIND phenotype: macrophage/microglia inflammation in neurocognitive disorders related to human immunodeficiency virus infection.In COS cells Vpu can both stabilize tetherin expression and counteract its antiviral activity.Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation.Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors.HIV-1 Vpu interference with innate cell-mediated immune mechanisms.HumanViCe: host ceRNA network in virus infected cells in human.HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?Endocytic activity of HIV-1 Vpu: Phosphoserine-dependent interactions with clathrin adaptors.HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling.MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins.HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes.Vpu is the main determinant for tetraspanin downregulation in HIV-1-infected cells.Brain-specific HIV Nef identified in multiple patients with neurological disease.DDX17 Specifically, and Independently of DDX5, Controls Use of the HIV A4/5 Splice Acceptor Cluster and Is Essential for Efficient Replication of HIV
P2860
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P2860
Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Misdirection of membrane traff ...... ral virulence and persistence.
@ast
Misdirection of membrane traff ...... ral virulence and persistence.
@en
type
label
Misdirection of membrane traff ...... ral virulence and persistence.
@ast
Misdirection of membrane traff ...... ral virulence and persistence.
@en
prefLabel
Misdirection of membrane traff ...... ral virulence and persistence.
@ast
Misdirection of membrane traff ...... ral virulence and persistence.
@en
P2860
P356
P1433
P1476
Misdirection of membrane traff ...... ral virulence and persistence.
@en
P2093
Andrey Tokarev
John Guatelli
P2860
P304
P356
10.4161/CL.1.3.16708
P577
2011-05-01T00:00:00Z