RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. - Test2 - elhamkhani - TriplyDB

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.

http://www.wikidata.org/entity/Q35216351

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G-quadruplexes and their regulatory roles in biology A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation.Metal Cations in G-Quadruplex Folding and Stability Do we know whether potential G-quadruplexes actually form in long functional RNA molecules?Modulation of the Translational Landscape During Herpesvirus Infection Commonalities between pain and memory mechanisms and their meaning for understanding chronic pain eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation G-Quadruplex in the NRF2 mRNA 5' Untranslated Region Regulates De Novo NRF2 Protein Translation under Oxidative Stress Tunable protein synthesis by transcript isoforms in human cells Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies Control of bacterial nitrate assimilation by stabilization of G-quadruplex DNA RiboDiff: detecting changes of mRNA translation efficiency from ribosome footprints.The RNA helicase, eIF4A-1, is required for ovule development and cell size homeostasis in Arabidopsis.The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation.New frontiers in translational control of the cancer genome Abrogating phosphorylation of eIF4B is required for EGFR and mTOR inhibitor synergy in triple-negative breast cancer.Transcriptome-wide characterization of the eIF4A signature highlights plasticity in translation regulation.Insights into the mechanisms of eukaryotic translation gained with ribosome profiling Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase.Targeting the eIF4F translation initiation complex: a critical nexus for cancer development eIF4A1 is a promising new therapeutic target in ER-negative breast cancer.Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication Differential Requirements for eIF4E Dose in Normal Development and Cancer 4E-BPs Control Fat Storage by Regulating the Expression of Egr1 and ATGL Pateamine A-sensitive ribosome profiling reveals the scope of translation in mouse embryonic stem cells nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs G4-associated human diseases.Extensive identification and analysis of conserved small ORFs in animals High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.Stabilization of the G-quadruplex at the VEGF IRES represses cap-independent translation.Differential Sensitivity of Target Genes to Translational Repression by miR-17~92.The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma.Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia Guanine quadruplex structures localize to heterochromatin.Translation Inhibition by Rocaglates Is Independent of eIF4E Phosphorylation Status.Identification of significantly mutated regions across cancer types highlights a rich landscape of functional molecular alterations Key contribution of eIF4H-mediated translational control in tumor promotion.A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity.The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis.

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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.

http://www.wikidata.org/entity/Q35216351

description

2014 nî lūn-bûn

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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2014 թվականի հուլիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.

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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.

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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.

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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.

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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.

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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.

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RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.

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Andrew L Wolfe

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Christina M Rodrigo

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Chunying Zhao

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Hans-Guido Wendel

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Jerry Pelletier

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John A Porco

http://www.w3.org/2001/XMLSchema#string

Joni Van der Meulen

http://www.w3.org/2001/XMLSchema#string

Justine E Roderick

http://www.w3.org/2001/XMLSchema#string

Kamini Singh

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Konstantinos J Mavrakis

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P2860

The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary

Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation

5'-UTR RNA G-quadruplexes: translation regulation and targeting

Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling

arrayCGHbase: an analysis platform for comparative genomic hybridization microarrays.

The Sequence Alignment/Map format and SAMtools

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

Vienna RNA secondary structure server

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

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Julie Teruya-Feldstein

Elisa de Stanchina

Jonathan H Schatz

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