Telomere fusions caused by mutating the terminal region of telomeric DNA
about
Stem cells, senescence, neosis and self-renewal in cancer.Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex.Rap1 prevents telomere fusions by nonhomologous end joining.Yeast telomerase is specialized for C/A-rich RNA templates.Telomerase can act as a template- and RNA-independent terminal transferase.Abrupt disruption of capping and a single source for recombinationally elongated telomeres in Kluyveromyces lactisA mutation in the STN1 gene triggers an alternative lengthening of telomere-like runaway recombinational telomere elongation and rapid deletion in yeast.Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joiningBalancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis.Dynamics of telomeric DNA turnover in yeast.Telomere maintenance as a target for anticancer drug discovery.The role of nonhomologous end-joining components in telomere metabolism in Kluyveromyces lactisGenetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae.Factors influencing the recombinational expansion and spread of telomeric tandem arrays in Kluyveromyces lactis.A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferationMutant telomeric repeats in yeast can disrupt the negative regulation of recombination-mediated telomere maintenance and create an alternative lengthening of telomeres-like phenotype.Genetic dissection of the Kluyveromyces lactis telomere and evidence for telomere capping defects in TER1 mutants with long telomeres.Targeting telomerase in hematologic malignancy.Taz1 binding to a fission yeast model telomere: formation of telomeric loops and higher order structures.Recombinational telomere elongation promoted by DNA circles.Template requirements for telomerase translocation in Kluyveromyces lactis.Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability.Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells.Telomere Dysfunction Triggers Palindrome Formation Independently of Double-Strand Break Repair Mechanisms.ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.Mitochondrial gene replacement in human pluripotent stem cell-derived neural progenitors.Chromosome termini of the monocot plant Othocallis siberica are maintained by telomerase, which specifically synthesises vertebrate-type telomere sequences.
P2860
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P2860
Telomere fusions caused by mutating the terminal region of telomeric DNA
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
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2000年論文
@zh-mo
2000年論文
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2000年论文
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Telomere fusions caused by mutating the terminal region of telomeric DNA
@ast
Telomere fusions caused by mutating the terminal region of telomeric DNA
@en
type
label
Telomere fusions caused by mutating the terminal region of telomeric DNA
@ast
Telomere fusions caused by mutating the terminal region of telomeric DNA
@en
prefLabel
Telomere fusions caused by mutating the terminal region of telomeric DNA
@ast
Telomere fusions caused by mutating the terminal region of telomeric DNA
@en
P2093
P2860
P356
P1476
Telomere fusions caused by mutating the terminal region of telomeric DNA
@en
P2093
P2860
P304
11409-11414
P356
10.1073/PNAS.210388397
P407
P577
2000-10-01T00:00:00Z